PDB entry 3sxr
View 3sxr on RCSB PDB site
Description: Crystal structure of BMX non-receptor tyrosine kinase complex with dasatinib
Class: transferase/transferase inhibitor
Keywords: transferase-transferase inhibitor complex
Deposited on
2011-07-15, released
2011-09-21
The last revision prior to the SCOPe 2.05 freeze date was dated
2011-11-30, with a file datestamp of
2011-11-25.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.189
AEROSPACI score: 0.35
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Cytoplasmic tyrosine-protein kinase BMX
Species: Homo sapiens [TaxId:9606]
Gene: AGMX1, ATK, BMX, BPK, BTK
Database cross-references and differences (RAF-indexed):
- Uniprot P51813 (3-End)
- expression tag (0-2)
- engineered mutation (24)
- engineered mutation (203)
- engineered mutation (209)
- engineered mutation (212)
Domains in SCOPe 2.05: d3sxra_ - Chain 'B':
Compound: Cytoplasmic tyrosine-protein kinase BMX
Species: Homo sapiens [TaxId:9606]
Gene: AGMX1, ATK, BMX, BPK, BTK
Database cross-references and differences (RAF-indexed):
- Uniprot P51813 (3-End)
- expression tag (0-2)
- engineered mutation (24)
- engineered mutation (203)
- engineered mutation (209)
- engineered mutation (212)
Domains in SCOPe 2.05: d3sxrb_ - Heterogens: 1N1, SO4, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3sxrA (A:)
ghmelkreeitllkelgsgqfgvvklgkwkgqydvavkmikegsmsedeffqeaqtmmkl
shpklvkfygvcskeypiyivteyisngcllnylrshgkglepsqllemcydvcegmafl
eshqfihrdlaarnclvdrdlcvkvsdfgmtryvlddqyvssvgtkfpvkwsapevfhyf
kyssksdvwafgilmwevfslgkmpydlytnsevvlkvsqghrlyrphlasdtiyqimys
cwhelpekrptfqqllssieplrekdkh
Sequence, based on observed residues (ATOM records): (download)
>3sxrA (A:)
ghmelkreeitllkelgsvvklgkwkgqydvavkmikegsmsedeffqeaqtmmklshpk
lvkfygvcskeypiyivteyisngcllnylrshgkglepsqllemcydvcegmafleshq
fihrdlaarnclvdrdlcvkvsdfgmtryvlddqyvssvgtkfpvkwsapevfhyfkyss
ksdvwafgilmwevfslgkmpydlytnsevvlkvsqghrlyrphlasdtiyqimyscwhe
lpekrptfqqllssieplre
- Chain 'B':
Sequence, based on SEQRES records: (download)
>3sxrB (B:)
ghmelkreeitllkelgsgqfgvvklgkwkgqydvavkmikegsmsedeffqeaqtmmkl
shpklvkfygvcskeypiyivteyisngcllnylrshgkglepsqllemcydvcegmafl
eshqfihrdlaarnclvdrdlcvkvsdfgmtryvlddqyvssvgtkfpvkwsapevfhyf
kyssksdvwafgilmwevfslgkmpydlytnsevvlkvsqghrlyrphlasdtiyqimys
cwhelpekrptfqqllssieplrekdkh
Sequence, based on observed residues (ATOM records): (download)
>3sxrB (B:)
ghmelkreeitllkelvvklgkwkgqydvavkmikegsmsedeffqeaqtmmklshpklv
kfygvcskeypiyivteyisngcllnylrshgkglepsqllemcydvcegmafleshqfi
hrdlaarnclvdrdlcvkvsdfgmtryvlddqyvssvgtkfpvkwsapevfhyfkyssks
dvwafgilmwevfslgkmpydlytnsevvlkvsqghrlyrphlasdtiyqimyscwhelp
ekrptfqqllssieplre