PDB entry 3sv6
View 3sv6 on RCSB PDB site
Description: Crystal structure of NS3/4A protease in complex with Telaprevir
Class: viral protein, hydrolase/inhibitor
Keywords: drug resistance, drug design, Protease inhibitors, serine protease, HYDROLASE, VIRAL PROTEIN, HYDROLASE-INHIBITOR complex
Deposited on
2011-07-12, released
2012-09-05
The last revision prior to the SCOPe 2.05 freeze date was dated
2012-09-05, with a file datestamp of
2012-08-31.
Experiment type: XRAY
Resolution: 1.4 Å
R-factor: 0.158
AEROSPACI score: 0.7
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: NS3 protease, NS4A protein
Species: Hepatitis C virus [TaxId:31646]
Gene: NS3-NS4A
Database cross-references and differences (RAF-indexed):
- Uniprot A8DG50 (6-20)
- expression tag (0-5)
- engineered mutation (6-9)
- see remark 999 (11)
- see remark 999 (18-19)
- Uniprot A8DG50 (21-End)
- engineered mutation (21-23)
- engineered mutation (33-34)
- engineered mutation (37-38)
- engineered mutation (41)
- engineered mutation (60)
- engineered mutation (67)
- engineered mutation (72)
- engineered mutation (92)
- engineered mutation (106)
- engineered mutation (179)
Domains in SCOPe 2.05: d3sv6a_ - Heterogens: SV6, GOL, SO4, ZN, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3sv6A (A:)
gshmasmkkkgsvvivgrinlsgdtayaqqtrgeegcqetsqtgrdknqvegevqivsta
tqtflatsingvlwtvyhgagtrtiaspkgpvtqmytnvdkdlvgwqapqgsrsltpctc
gssdlylvtrhadvipvrrrgdsrgsllsprpisylkgssggpllcpaghavgifraavs
trgvakavdfipveslettmrsp
Sequence, based on observed residues (ATOM records): (download)
>3sv6A (A:)
gshmasmkkkgsvvivgrinlsgdtayaqqtrgeegcqetsqtgrdknqvegevqivsta
tqtflatsingvlwtvyhgagtrtiaspkgpvtqmytnvdkdlvgwqapqgsrsltpctc
gssdlylvtrhadvipvrrrgdsrgsllsprpisylkgssggpllcpaghavgifraavs
trgvakavdfipveslettmrs