PDB entry 3su0
View 3su0 on RCSB PDB site
Description: Crystal structure of NS3/4A protease variant R155K in complex with danoprevir
Class: hydrolase/hydrolase inhibitor
Keywords: NS3, drug resistance, drug design, Protease inhibitors, HCV, serine protease, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on
2011-07-11, released
2012-09-05
The last revision prior to the SCOPe 2.08 freeze date was dated
2017-11-08, with a file datestamp of
2017-11-03.
Experiment type: XRAY
Resolution: 1.16 Å
R-factor: N/A
AEROSPACI score: 0.68
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Genome polyprotein
Species: Hepatitis C virus subtype 1a [TaxId:31646]
Gene: NS3-NS4A
Database cross-references and differences (RAF-indexed):
- Uniprot A8DG50 (7-17)
- expression tag (0-2)
- engineered mutation (3-6)
- see remark 999 (8)
- see remark 999 (15-16)
- engineered mutation (18-20)
- Uniprot A8DG50 (21-197)
- engineered mutation (30-31)
- engineered mutation (34-35)
- engineered mutation (38)
- engineered mutation (57)
- engineered mutation (64)
- engineered mutation (69)
- engineered mutation (89)
- engineered mutation (103)
- engineered mutation (156)
- engineered mutation (172)
- engineered mutation (176)
Domains in SCOPe 2.08: d3su0a1, d3su0a2 - Heterogens: TSV, SO4, ZN, HOH