PDB entry 3sr4

View 3sr4 on RCSB PDB site
Description: Crystal Structure of Human DOT1L in Complex with a Selective Inhibitor
Class: transferase/transferase inhibitor
Keywords: HDOT1, HISTONE LYSINE METHYLTRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2011-07-06, released 2011-10-05
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-11-16, with a file datestamp of 2011-11-11.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.234
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histone-lysine N-methyltransferase, H3 lysine-79 specific
    Species: Homo sapiens [TaxId:9606]
    Gene: DOT1L, KIAA1814, KMT4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3sr4a_
  • Heterogens: TT8, GOL, ACT, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3sr4A (A:)
mgeklelrlkspvgaepavypwplpvydkhhdaaheiietirwvceeipdlklamenyvl
idydtksfesmqrlcdkynraidsihqlwkgttqpmklntrpstgllrhilqqvynhsvt
dpeklnnyepfspevygetsfdlvaqmideikmtdddlfvdlgsgvgqvvlqvaaatnck
hhygvekadipakyaetmdrefrkwmkwygkkhaeytlergdflseewreriantsvifv
nnfafgpevdhqlkerfanmkeggrivsskpfaplnfrinsrnlsdigtimrvvelsplk
gsvswtgkpvsyylhtidrtilenyfsslknpklreeqeaarrrqqresks

    Sequence, based on observed residues (ATOM records): (download) 
    >3sr4A (A:)
lelrlkspvgaepavypwplpvydkhhdaaheiietirwvceeipdlklamenyvlidyd
tksfesmqrlcdkynraidsihqlwkgttqpmklntrpstgllrhilqqvynhsvtdpek
lnnyepfspevygetsfdlvaqmideikmtdddlfvdlgsgvgqvvlqvaaatnckhhyg
vekadipakyaetmdrefrkwmkwygkkhaeytlergdflseewreriantsvifvnnfa
fgpevdhqlkerfanmkeggrivsskpfaplnfrinsrnlsdigtimrvvelsplkgsvs
wtgkpvsyylhtidrtilenyfsslknp