PDB entry 3sqp

View 3sqp on RCSB PDB site
Description: Structure of human glutathione reductase complexed with pyocyanin, an agent with antimalarial activity
Class: oxidoreductase/antibiotic
Keywords: CELLULAR REDUCTANTS, GLUTATHIONE REDUCTASE, PLASMODIUM FALCIPARUM, PYOCYANIN, ALTERNATIVE INITIATION, FLAVOPROTEIN, MITOCHONDRION, OXIDOREDUCTASE, PHOSPHOPROTEIN, REDOX-ACTIVE CENTER, TRANSIT PEPTIDE, OXIDOREDUCTASE-ANTIBIOTIC complex
Deposited on 2011-07-06, released 2011-09-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-12-10, with a file datestamp of 2014-12-05.
Experiment type: XRAY
Resolution: 2.21 Å
R-factor: 0.146
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: glutathione reductase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3sqpa1, d3sqpa2, d3sqpa3
  • Chain 'B':
    Compound: glutathione reductase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3sqpb1, d3sqpb2, d3sqpb3
  • Heterogens: FAD, SO4, 3J8, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3sqpA (A:)
acrqepqpqgpppaagavasydylvigggsgglasarraaelgaraavveshklggtcvn
vgcvpkkvmwntavhsefmhdhadygfpscegkfnwrvikekrdayvsrlnaiyqnnltk
shieiirghaaftsdpkptievsgkkytaphiliatggmpstphesqipgaslgitsdgf
fqleelpgrsvivgagyiavemagilsalgsktslmirhdkvlrsfdsmistncteelen
agvevlkfsqvkevkktlsglevsmvtavpgrlpvmtmipdvdcllwaigrvpntkdlsl
nklgiqtddkghiivdefqntnvkgiyavgdvcgkalltpvaiaagrklahrlfeykeds
kldynniptvvfshppigtvgltedeaihkygienvktystsftpmyhavtkrktkcvmk
mvcankeekvvgihmqglgcdemlqgfavavkmgatkadfdntvaihptsseelvtlr

    Sequence, based on observed residues (ATOM records): (download) 
    >3sqpA (A:)
vasydylvigggsgglasarraaelgaraavveshklggtcvnvgcvpkkvmwntavhse
fmhdhadygfpscegkfnwrvikekrdayvsrlnaiyqnnltkshieiirghaaftsdpk
ptievsgkkytaphiliatggmpstphesqipgaslgitsdgffqleelpgrsvivgagy
iavemagilsalgsktslmirhdkvlrsfdsmistncteelenagvevlkfsqvkevkkt
lsglevsmvtavpgrlpvmtmipdvdcllwaigrvpntkdlslnklgiqtddkghiivde
fqntnvkgiyavgdvcgkalltpvaiaagrklahrlfeykedskldynniptvvfshppi
gtvgltedeaihkygienvktystsftpmyhavtkrktkcvmkmvcankeekvvgihmqg
lgcdemlqgfavavkmgatkadfdntvaihptsseelvtlr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3sqpB (B:)
acrqepqpqgpppaagavasydylvigggsgglasarraaelgaraavveshklggtcvn
vgcvpkkvmwntavhsefmhdhadygfpscegkfnwrvikekrdayvsrlnaiyqnnltk
shieiirghaaftsdpkptievsgkkytaphiliatggmpstphesqipgaslgitsdgf
fqleelpgrsvivgagyiavemagilsalgsktslmirhdkvlrsfdsmistncteelen
agvevlkfsqvkevkktlsglevsmvtavpgrlpvmtmipdvdcllwaigrvpntkdlsl
nklgiqtddkghiivdefqntnvkgiyavgdvcgkalltpvaiaagrklahrlfeykeds
kldynniptvvfshppigtvgltedeaihkygienvktystsftpmyhavtkrktkcvmk
mvcankeekvvgihmqglgcdemlqgfavavkmgatkadfdntvaihptsseelvtlr

    Sequence, based on observed residues (ATOM records): (download) 
    >3sqpB (B:)
vasydylvigggsgglasarraaelgaraavveshklggtcvnvgcvpkkvmwntavhse
fmhdhadygfpscegkfnwrvikekrdayvsrlnaiyqnnltkshieiirghaaftsdpk
ptievsgkkytaphiliatggmpstphesqipgaslgitsdgffqleelpgrsvivgagy
iavemagilsalgsktslmirhdkvlrsfdsmistncteelenagvevlkfsqvkevkkt
lsglevsmvtavpgrlpvmtmipdvdcllwaigrvpntkdlslnklgiqtddkghiivde
fqntnvkgiyavgdvcgkalltpvaiaagrklahrlfeykedskldynniptvvfshppi
gtvgltedeaihkygienvktystsftpmyhavtkrktkcvmkmvcankeekvvgihmqg
lgcdemlqgfavavkmgatkadfdntvaihptsseelvtlr