SCOPe 2.08: Structural Classification of Proteins

PDB entry 3sq8

View 3sq8 on RCSB PDB site
Description: Crystal Structure Analysis of the Yeast Tyrosyl-DNA Phosphodiesterase 1 H432R Mutant (SCAN1 Mutant)
Class: hydrolase
Keywords: Phosphodiesterase, DNA Binding, NUCLEAR, HYDROLASE
Deposited on 2011-07-05, released 2011-12-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2012-03-14, with a file datestamp of 2012-03-09.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.189
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: tyrosyl-DNA phosphodiesterase 1
Species: Saccharomyces cerevisiae [TaxId:559292]
Gene: TDP1, YBR223C, YBR1520
Database cross-references and differences (RAF-indexed):
- Uniprot P38319 (1-461)
  - engineered mutation (354)
Domains in SCOPe 2.08: d3sq8a1, d3sq8a2
Chain 'B':
Compound: tyrosyl-DNA phosphodiesterase 1
Species: Saccharomyces cerevisiae [TaxId:559292]
Gene: TDP1, YBR223C, YBR1520
Database cross-references and differences (RAF-indexed):
- Uniprot P38319 (1-461)
  - engineered mutation (354)
  - expression tag (462-463)
Domains in SCOPe 2.08: d3sq8b1, d3sq8b2, d3sq8b3
Chain 'C':
Compound: tyrosyl-DNA phosphodiesterase 1
Species: Saccharomyces cerevisiae [TaxId:559292]
Gene: TDP1, YBR223C, YBR1520
Database cross-references and differences (RAF-indexed):
- Uniprot P38319 (1-461)
  - engineered mutation (354)
  - expression tag (462-463)
Domains in SCOPe 2.08: d3sq8c1, d3sq8c2, d3sq8c3
Chain 'D':
Compound: tyrosyl-DNA phosphodiesterase 1
Species: Saccharomyces cerevisiae [TaxId:559292]
Gene: TDP1, YBR223C, YBR1520
Database cross-references and differences (RAF-indexed):
- Uniprot P38319 (1-461)
  - engineered mutation (354)
  - expression tag (462-464)
Domains in SCOPe 2.08: d3sq8d1, d3sq8d2, d3sq8d3
Heterogens: HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>3sq8A (A:)
mgavfklmksdfyeredfmgevedmitlkdifgtetlkrsilfsfqyeldfllrqfhqnv
enitivgqkgtimpiearamdatlavilkkvklieitmppfashhtkliinfydngecki
flpsnnftsmetnlpqqvcwcspllkigkeglpvpfkrslieylnsyhlkdidelitksv
eevnfaplselefvystpskfqssgllsfynkleklsagtsasdtakhylcqtssigtsl
srardenlwthlmiplftgimsppakdtagrkkaeilptnslineysqrkikpyiifpte
qefvtsplkwsssgwfhfqylqkksyyemlrnkfkvfykqdpamvtrrrgttparskfym
hcatnsagpcdasqvfkelewclytsanlsqtawgtvsrkprnyeagvlyhsrrlantrk
vtcrtftrdrrgcagnpthvavpftlpvipydlaedecfclalhhhhhhh

Sequence, based on observed residues (ATOM records): (download)

>3sq8A (A:)
gavfklmksdfyeredmitlkdifgtetlkrsilfsfqyeldfllrqfhqnvenitivgq
kgtimpiearamdatlavilkkvklieitmppfashhtkliinfydngeckiflpsnnft
smetnlpqqvcwcspllkigkeglpvpfkrslieylnsyhlkdidelitksveevnfapl
selefvystpskfqssgllsfynkleklsdtakhylcqtssigtslsrardenlwthlmi
plftgimsppilptnslineysqrkikpyiifpteqefvtsplkwsssgwfhfqylqkks
yyemlrnkfkvfykqdpamvtrrrgttparskfymhcatsqvfkelewclytsanlsqta
wgtvsrkprnyeagvlyhsrrlantrkvtcrtftrdpthvavpftlpvipydlaedecfc
la

Chain 'B':
Sequence, based on SEQRES records: (download)

>3sq8B (B:)
mgavfklmksdfyeredfmgevedmitlkdifgtetlkrsilfsfqyeldfllrqfhqnv
enitivgqkgtimpiearamdatlavilkkvklieitmppfashhtkliinfydngecki
flpsnnftsmetnlpqqvcwcspllkigkeglpvpfkrslieylnsyhlkdidelitksv
eevnfaplselefvystpskfqssgllsfynkleklsagtsasdtakhylcqtssigtsl
srardenlwthlmiplftgimsppakdtagrkkaeilptnslineysqrkikpyiifpte
qefvtsplkwsssgwfhfqylqkksyyemlrnkfkvfykqdpamvtrrrgttparskfym
hcatnsagpcdasqvfkelewclytsanlsqtawgtvsrkprnyeagvlyhsrrlantrk
vtcrtftrdrrgcagnpthvavpftlpvipydlaedecfclalhhhhhhh

Sequence, based on observed residues (ATOM records): (download)

>3sq8B (B:)
gavfklmksdfyeredmitlkdifgtetlkrsilfsfqyeldfllrqfhqnvenitivgq
kgtimpiearamdatlavilkkvklieitmppfashhtkliinfydngeckiflpsnnft
smetnlpqqvcwcspllkigkeglpvpfkrslieylnsyhlkdidelitksveevnfapl
selefvystpskfqssgllsfynkleklsdtakhylcqtssigtslsrardenlwthlmi
plftgimsppilptnslineysqrkikpyiifpteqefvtsplkwsssgwfhfqylqkks
yyemlrnkfkvfykqdpamvtrrrgttparskfymhcatnsqvfkelewclytsanlsqt
awgtvsrkprnyeagvlyhsrrlarkvtcrtftrdpthvavpftlpvipydlaedecfcl
alh

Chain 'C':
Sequence, based on SEQRES records: (download)

>3sq8C (C:)
mgavfklmksdfyeredfmgevedmitlkdifgtetlkrsilfsfqyeldfllrqfhqnv
enitivgqkgtimpiearamdatlavilkkvklieitmppfashhtkliinfydngecki
flpsnnftsmetnlpqqvcwcspllkigkeglpvpfkrslieylnsyhlkdidelitksv
eevnfaplselefvystpskfqssgllsfynkleklsagtsasdtakhylcqtssigtsl
srardenlwthlmiplftgimsppakdtagrkkaeilptnslineysqrkikpyiifpte
qefvtsplkwsssgwfhfqylqkksyyemlrnkfkvfykqdpamvtrrrgttparskfym
hcatnsagpcdasqvfkelewclytsanlsqtawgtvsrkprnyeagvlyhsrrlantrk
vtcrtftrdrrgcagnpthvavpftlpvipydlaedecfclalhhhhhhh

Sequence, based on observed residues (ATOM records): (download)

>3sq8C (C:)
gavfklmksdfyeredmitlkdifgtetlkrsilfsfqyeldfllrqfhqnvenitivgq
kgtimpiearamdatlavilkkvklieitmppfashhtkliinfydngeckiflpsnnft
smetnlpqqvcwcspllkigkeglpvpfkrslieylnsyhlkdidelitksveevnfapl
selefvystpskfqssgllsfynkleklsdtakhylcqtssigtslsrardenlwthlmi
plftgimsppilptnslineysqrkikpyiifpteqefvtsplkwsssgwfhfqylqkks
yyemlrnkfkvfykqdpamvtrrrgttparskfymhcatnsqvfkelewclytsanlsqt
awgtvsrkprnyeagvlyhsrrlarkvtcrtftrdpthvavpftlpvipydlaedecfcl
alh

Chain 'D':
Sequence, based on SEQRES records: (download)

>3sq8D (D:)
mgavfklmksdfyeredfmgevedmitlkdifgtetlkrsilfsfqyeldfllrqfhqnv
enitivgqkgtimpiearamdatlavilkkvklieitmppfashhtkliinfydngecki
flpsnnftsmetnlpqqvcwcspllkigkeglpvpfkrslieylnsyhlkdidelitksv
eevnfaplselefvystpskfqssgllsfynkleklsagtsasdtakhylcqtssigtsl
srardenlwthlmiplftgimsppakdtagrkkaeilptnslineysqrkikpyiifpte
qefvtsplkwsssgwfhfqylqkksyyemlrnkfkvfykqdpamvtrrrgttparskfym
hcatnsagpcdasqvfkelewclytsanlsqtawgtvsrkprnyeagvlyhsrrlantrk
vtcrtftrdrrgcagnpthvavpftlpvipydlaedecfclalhhhhhhh

Sequence, based on observed residues (ATOM records): (download)

>3sq8D (D:)
gavfklmksdfyeredmitlkdifgtetlkrsilfsfqyeldfllrqfhqnvenitivgq
kgtimpiearamdatlavilkkvklieitmppfashhtkliinfydngeckiflpsnnft
smetnlpqqvcwcspllkigkeglpvpfkrslieylnsyhlkdidelitksveevnfapl
selefvystpskfqssgllsfynkleklsdtakhylcqtssigtslsrardenlwthlmi
plftgimsppilptnslineysqrkikpyiifpteqefvtsplkwsssgwfhfqylqkks
yyemlrnkfkvfykqdpamvtrrrgttparskfymhcatnsqvfkelewclytsanlsqt
awgtvsrkprnyeagvlyhsrrlatrkvtcrtftrdpthvavpftlpvipydlaedecfc
lalhh