SCOPe 2.08: Structural Classification of Proteins

PDB entry 3sq7

View 3sq7 on RCSB PDB site
Description: Crystal Structure Analysis of the Yeast Tyrosyl-DNA Phosphodiesterase H432N_Glu Mutant
Class: hydrolase
Keywords: Phosphodiesterase, DNA Binding, NUCLEAR, HYDROLASE
Deposited on 2011-07-05, released 2011-12-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2012-03-14, with a file datestamp of 2012-03-09.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.176
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: tyrosyl-DNA phosphodiesterase 1
Species: Saccharomyces cerevisiae [TaxId:559292]
Gene: TDP1, YBR223C, YBR1520
Database cross-references and differences (RAF-indexed):
- Uniprot P38319 (1-461)
  - engineered mutation (354)
  - expression tag (462-465)
Domains in SCOPe 2.08: d3sq7a1, d3sq7a2, d3sq7a3
Chain 'B':
Compound: tyrosyl-DNA phosphodiesterase 1
Species: Saccharomyces cerevisiae [TaxId:559292]
Gene: TDP1, YBR223C, YBR1520
Database cross-references and differences (RAF-indexed):
- Uniprot P38319 (1-461)
  - engineered mutation (354)
  - expression tag (462-467)
Domains in SCOPe 2.08: d3sq7b1, d3sq7b2, d3sq7b3
Chain 'C':
Compound: tyrosyl-DNA phosphodiesterase 1
Species: Saccharomyces cerevisiae [TaxId:559292]
Gene: TDP1, YBR223C, YBR1520
Database cross-references and differences (RAF-indexed):
- Uniprot P38319 (1-461)
  - engineered mutation (354)
  - expression tag (462-466)
Domains in SCOPe 2.08: d3sq7c1, d3sq7c2, d3sq7c3
Chain 'D':
Compound: tyrosyl-DNA phosphodiesterase 1
Species: Saccharomyces cerevisiae [TaxId:559292]
Gene: TDP1, YBR223C, YBR1520
Database cross-references and differences (RAF-indexed):
- Uniprot P38319 (1-461)
  - engineered mutation (354)
  - expression tag (462-467)
Domains in SCOPe 2.08: d3sq7d1, d3sq7d2, d3sq7d3
Heterogens: SO4, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>3sq7A (A:)
mgavfklmksdfyeredfmgevedmitlkdifgtetlkrsilfsfqyeldfllrqfhqnv
enitivgqkgtimpiearamdatlavilkkvklieitmppfashhtkliinfydngecki
flpsnnftsmetnlpqqvcwcspllkigkeglpvpfkrslieylnsyhlkdidelitksv
eevnfaplselefvystpskfqssgllsfynkleklsagtsasdtakhylcqtssigtsl
srardenlwthlmiplftgimsppakdtagrkkaeilptnslineysqrkikpyiifpte
qefvtsplkwsssgwfhfqylqkksyyemlrnkfkvfykqdpamvtrrrgttpanskfym
hcatnsagpcdasqvfkelewclytsanlsqtawgtvsrkprnyeagvlyhsrrlantrk
vtcrtftrdrrgcagnpthvavpftlpvipydlaedecfclalehhhhhh

Sequence, based on observed residues (ATOM records): (download)

>3sq7A (A:)
gavfklmksdfyeredmitlkdifgtetlkrsilfsfqyeldfllrqfhqnvenitivgq
kgtimpiearamdatlavilkkvklieitmppfashhtkliinfydngeckiflpsnnft
smetnlpqqvcwcspllkigkeglpvpfkrslieylnsyhlkdidelitksveevnfapl
selefvystpskfqssgllsfynkleklsagtsasdtakhylcqtssigtslsrardenl
wthlmiplftgimsppilptnslineysqrkikpyiifpteqefvtsplkwsssgwfhfq
ylqkksyyemlrnkfkvfykqdpamvtrrrgttpanskfymhcatsqvfkelewclytsa
nlsqtawgtvsrkprnyeagvlyhsrrlantrkvtcrtftrdpthvavpftlpvipydla
edecfclalehh

Chain 'B':
Sequence, based on SEQRES records: (download)

>3sq7B (B:)
mgavfklmksdfyeredfmgevedmitlkdifgtetlkrsilfsfqyeldfllrqfhqnv
enitivgqkgtimpiearamdatlavilkkvklieitmppfashhtkliinfydngecki
flpsnnftsmetnlpqqvcwcspllkigkeglpvpfkrslieylnsyhlkdidelitksv
eevnfaplselefvystpskfqssgllsfynkleklsagtsasdtakhylcqtssigtsl
srardenlwthlmiplftgimsppakdtagrkkaeilptnslineysqrkikpyiifpte
qefvtsplkwsssgwfhfqylqkksyyemlrnkfkvfykqdpamvtrrrgttpanskfym
hcatnsagpcdasqvfkelewclytsanlsqtawgtvsrkprnyeagvlyhsrrlantrk
vtcrtftrdrrgcagnpthvavpftlpvipydlaedecfclalehhhhhh

Sequence, based on observed residues (ATOM records): (download)

>3sq7B (B:)
gavfklmksdfyedmitlkdifgtetlkrsilfsfqyeldfllrqfhqnvenitivgqkg
timpiearamdatlavilkkvklieitmpashhtkliinfydngeckiflpsnnftsmet
nlpqqvcwcspllkigkeglpvpfkrslieylnsyhlkdidelitksveevnfaplsele
fvystpskfqssgllsfynkleklsdtakhylcqtssigtslsrardenlwthlmiplft
gimsppilptnslineysqrkikpyiifpteqefvtsplkwsssgwfhfqylqkksyyem
lrnkfkvfykqdpamvtrrrgttpanskfymhcatnsqvfkelewclytsanlsqtawgt
vsrkprnyeagvlyhsrrlantrkvtcrtftrdnpthvavpftlpvipydlaedecfcla
lehhhh

Chain 'C':
Sequence, based on SEQRES records: (download)

>3sq7C (C:)
mgavfklmksdfyeredfmgevedmitlkdifgtetlkrsilfsfqyeldfllrqfhqnv
enitivgqkgtimpiearamdatlavilkkvklieitmppfashhtkliinfydngecki
flpsnnftsmetnlpqqvcwcspllkigkeglpvpfkrslieylnsyhlkdidelitksv
eevnfaplselefvystpskfqssgllsfynkleklsagtsasdtakhylcqtssigtsl
srardenlwthlmiplftgimsppakdtagrkkaeilptnslineysqrkikpyiifpte
qefvtsplkwsssgwfhfqylqkksyyemlrnkfkvfykqdpamvtrrrgttpanskfym
hcatnsagpcdasqvfkelewclytsanlsqtawgtvsrkprnyeagvlyhsrrlantrk
vtcrtftrdrrgcagnpthvavpftlpvipydlaedecfclalehhhhhh

Sequence, based on observed residues (ATOM records): (download)

>3sq7C (C:)
gavfklmksdfyeredmitlkdifgtetlkrsilfsfqyeldfllrqfhqnvenitivgq
kgtimpiearamdatlavilkkvklieitmppfashhtkliinfydngeckiflpsnnft
smetnlpqqvcwcspllkigkeglpvpfkrslieylnsyhlkdidelitksveevnfapl
selefvystpskfqssgllsfynkleklsasdtakhylcqtssigtslsrardenlwthl
miplftgimsppilptnslineysqrkikpyiifpteqefvtsplkwsssgwfhfqylqk
ksyyemlrnkfkvfykqdpamvtrrrgttpanskfymhcatnsqvfkelewclytsanls
qtawgtvsrkprnyeagvlyhsrrlantrkvtcrtftrdpthvavpftlpvipydlaede
cfclalehhh

Chain 'D':
Sequence, based on SEQRES records: (download)

>3sq7D (D:)
mgavfklmksdfyeredfmgevedmitlkdifgtetlkrsilfsfqyeldfllrqfhqnv
enitivgqkgtimpiearamdatlavilkkvklieitmppfashhtkliinfydngecki
flpsnnftsmetnlpqqvcwcspllkigkeglpvpfkrslieylnsyhlkdidelitksv
eevnfaplselefvystpskfqssgllsfynkleklsagtsasdtakhylcqtssigtsl
srardenlwthlmiplftgimsppakdtagrkkaeilptnslineysqrkikpyiifpte
qefvtsplkwsssgwfhfqylqkksyyemlrnkfkvfykqdpamvtrrrgttpanskfym
hcatnsagpcdasqvfkelewclytsanlsqtawgtvsrkprnyeagvlyhsrrlantrk
vtcrtftrdrrgcagnpthvavpftlpvipydlaedecfclalehhhhhh

Sequence, based on observed residues (ATOM records): (download)

>3sq7D (D:)
gavfklmksdfyerdmitlkdifgtetlkrsilfsfqyeldfllrqfhqnvenitivgqk
gtimpiearamdatlavilkkvklieitmppashhtkliinfydngeckiflpsnnftsm
etnlpqqvcwcspllkigkeglpvpfkrslieylnsyhlkdidelitksveevnfaplse
lefvystpskfqssgllsfynkleklstakhylcqtssigtslsrardenlwthlmiplf
tgimsppilptnslineysqrkikpyiifpteqefvtsplkwsssgwfhfqylqkksyye
mlrnkfkvfykqdpamvtrrrgttpanskfymhcatsqvfkelewclytsanlsqtawgt
vsrkprnyeagvlyhsrrlantrkvtcrtftrdpthvavpftlpvipydlaedecfclal
ehhhh