SCOPe 2.08: Structural Classification of Proteins

PDB entry 3sq3

View 3sq3 on RCSB PDB site
Description: Crystal Structure Analysis of the Yeast Tyrosyl-DNA Phosphodiesterase H182A Mutant
Class: hydrolase
Keywords: Phosphodiesterase, DNA Binding, NUCLEAR, HYDROLASE
Deposited on 2011-07-04, released 2011-12-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2012-03-14, with a file datestamp of 2012-03-09.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.206
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: tyrosyl-DNA phosphodiesterase 1
Species: Saccharomyces cerevisiae [TaxId:559292]
Gene: TDP1, YBR223C, YBR1520
Database cross-references and differences (RAF-indexed):
- Uniprot P38319 (1-461)
  - engineered mutation (104)
  - expression tag (462)
Domains in SCOPe 2.08: d3sq3a1, d3sq3a2, d3sq3a3
Chain 'B':
Compound: tyrosyl-DNA phosphodiesterase 1
Species: Saccharomyces cerevisiae [TaxId:559292]
Gene: TDP1, YBR223C, YBR1520
Database cross-references and differences (RAF-indexed):
- Uniprot P38319 (1-461)
  - engineered mutation (104)
Domains in SCOPe 2.08: d3sq3b1, d3sq3b2
Chain 'C':
Compound: tyrosyl-DNA phosphodiesterase 1
Species: Saccharomyces cerevisiae [TaxId:559292]
Gene: TDP1, YBR223C, YBR1520
Database cross-references and differences (RAF-indexed):
- Uniprot P38319 (1-End)
  - engineered mutation (104)
Domains in SCOPe 2.08: d3sq3c1, d3sq3c2
Chain 'D':
Compound: tyrosyl-DNA phosphodiesterase 1
Species: Saccharomyces cerevisiae [TaxId:559292]
Gene: TDP1, YBR223C, YBR1520
Database cross-references and differences (RAF-indexed):
- Uniprot P38319 (1-461)
  - engineered mutation (104)
  - expression tag (462)
Domains in SCOPe 2.08: d3sq3d1, d3sq3d2, d3sq3d3

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>3sq3A (A:)
mgavfklmksdfyeredfmgevedmitlkdifgtetlkrsilfsfqyeldfllrqfhqnv
enitivgqkgtimpiearamdatlavilkkvklieitmppfashatkliinfydngecki
flpsnnftsmetnlpqqvcwcspllkigkeglpvpfkrslieylnsyhlkdidelitksv
eevnfaplselefvystpskfqssgllsfynkleklsagtsasdtakhylcqtssigtsl
srardenlwthlmiplftgimsppakdtagrkkaeilptnslineysqrkikpyiifpte
qefvtsplkwsssgwfhfqylqkksyyemlrnkfkvfykqdpamvtrrrgttpahskfym
hcatnsagpcdasqvfkelewclytsanlsqtawgtvsrkprnyeagvlyhsrrlantrk
vtcrtftrdrrgcagnpthvavpftlpvipydlaedecfclalhhhhhhh

Sequence, based on observed residues (ATOM records): (download)

>3sq3A (A:)
gavfklmksdfyeredmitlkdifgtetlkrsilfsfqyeldfllrqfhqnvenitivgq
kgtimpiearamdatlavilkkvklieitmppfashatkliinfydngeckiflpsnnft
smetnlpqqvcwcspllkigkeglpvpfkrslieylnsyhlkdidelitksveevnfapl
selefvystpskfqssgllsfynkleklsdtakhylcqtssigtslsrardenlwthlmi
plftgimsppilptnslineysqrkikpyiifpteqefvtsplkwsssgwfhfqylqkks
yyemlrnkfkvfykqdpamvtrrrgttpahskfymhcatnsqvfkelewclytsanlsqt
awgtvsrkprnyeagvlyhsrrlantrkvtcrtftrdpthvavpftlpvipydlaedecf
clal

Chain 'B':
Sequence, based on SEQRES records: (download)

>3sq3B (B:)
mgavfklmksdfyeredfmgevedmitlkdifgtetlkrsilfsfqyeldfllrqfhqnv
enitivgqkgtimpiearamdatlavilkkvklieitmppfashatkliinfydngecki
flpsnnftsmetnlpqqvcwcspllkigkeglpvpfkrslieylnsyhlkdidelitksv
eevnfaplselefvystpskfqssgllsfynkleklsagtsasdtakhylcqtssigtsl
srardenlwthlmiplftgimsppakdtagrkkaeilptnslineysqrkikpyiifpte
qefvtsplkwsssgwfhfqylqkksyyemlrnkfkvfykqdpamvtrrrgttpahskfym
hcatnsagpcdasqvfkelewclytsanlsqtawgtvsrkprnyeagvlyhsrrlantrk
vtcrtftrdrrgcagnpthvavpftlpvipydlaedecfclalhhhhhhh

Sequence, based on observed residues (ATOM records): (download)

>3sq3B (B:)
gavfklmksdfyeredmitlkdifgtetlkrsilfsfqyeldfllrqfhqnvenitivgq
kgtimpiearamdatlavilkkvklieitmppfashatkliinfydngeckiflpsnnft
smetnlpqqvcwcspllkigkeglpvpfkrslieylnsyhlkdidelitksveevnfapl
selefvystpskfqssgllsfynkleklsdtakhylcqtssigtslsrardenlwthlmi
plftgimsppilptnslineysqrkikpyiifpteqefvtsplkwsssgwfhfqylqkks
yyemlrnkfkvfykqdpamvtrrrgttpahskfymhcatnsqvfkelewclytsanlsqt
awgtvsrkprnyeagvlyhsrrlantrkvtcrtftrdpthvavpftlpvipydlaedecf
cla

Chain 'C':
Sequence, based on SEQRES records: (download)

>3sq3C (C:)
mgavfklmksdfyeredfmgevedmitlkdifgtetlkrsilfsfqyeldfllrqfhqnv
enitivgqkgtimpiearamdatlavilkkvklieitmppfashatkliinfydngecki
flpsnnftsmetnlpqqvcwcspllkigkeglpvpfkrslieylnsyhlkdidelitksv
eevnfaplselefvystpskfqssgllsfynkleklsagtsasdtakhylcqtssigtsl
srardenlwthlmiplftgimsppakdtagrkkaeilptnslineysqrkikpyiifpte
qefvtsplkwsssgwfhfqylqkksyyemlrnkfkvfykqdpamvtrrrgttpahskfym
hcatnsagpcdasqvfkelewclytsanlsqtawgtvsrkprnyeagvlyhsrrlantrk
vtcrtftrdrrgcagnpthvavpftlpvipydlaedecfclalhhhhhhh

Sequence, based on observed residues (ATOM records): (download)

>3sq3C (C:)
gavfklmksdfyeredmitlkdifgtetlkrsilfsfqyeldfllrqfhqnvenitivgq
kgtimpiearamdatlavilkkvklieitmppfashatkliinfydngeckiflpsnnft
smetnlpqqvcwcspllkigkeglpvpfkrslieylnsyhlkdidelitksveevnfapl
selefvystpskfqssgllsfynkleklsdtakhylcqtssigtslsrardenlwthlmi
plftgimsppilptnslineysqrkikpyiifpteqefvtsplkwsssgwfhfqylqkks
yyemlrnkfkvfykqdpamvtrrrgttpahskfymhcatnsqvfkelewclytsanlsqt
awgtvsrkprnyeagvlyhsrrlantrkvtcrtftrdpthvavpftlpvipydlaedecf
cl

Chain 'D':
Sequence, based on SEQRES records: (download)

>3sq3D (D:)
mgavfklmksdfyeredfmgevedmitlkdifgtetlkrsilfsfqyeldfllrqfhqnv
enitivgqkgtimpiearamdatlavilkkvklieitmppfashatkliinfydngecki
flpsnnftsmetnlpqqvcwcspllkigkeglpvpfkrslieylnsyhlkdidelitksv
eevnfaplselefvystpskfqssgllsfynkleklsagtsasdtakhylcqtssigtsl
srardenlwthlmiplftgimsppakdtagrkkaeilptnslineysqrkikpyiifpte
qefvtsplkwsssgwfhfqylqkksyyemlrnkfkvfykqdpamvtrrrgttpahskfym
hcatnsagpcdasqvfkelewclytsanlsqtawgtvsrkprnyeagvlyhsrrlantrk
vtcrtftrdrrgcagnpthvavpftlpvipydlaedecfclalhhhhhhh

Sequence, based on observed residues (ATOM records): (download)

>3sq3D (D:)
gavfklmksdfyeredmitlkdifgtetlkrsilfsfqyeldfllrqfhqnvenitivgq
kgtimpiearamdatlavilkkvklieitmppfashatkliinfydngeckiflpsnnft
smetnlpqqvcwcspllkigkeglpvpfkrslieylnsyhlkdidelitksveevnfapl
selefvystpskfqssgllsfynkleklsdtakhylcqtssigtslsrardenlwthlmi
plftgimsppilptnslineysqrkikpyiifpteqefvtsplkwsssgwfhfqylqkks
yyemlrnkfkvfykqdpamvtrrrgttpahskfymhcatnsqvfkelewclytsanlsqt
awgtvsrkprnyeagvlyhsrrlantrkvtcrtftrdpthvavpftlpvipydlaedecf
clal