PDB entry 3sls
View 3sls on RCSB PDB site
Description: Crystal Structure of human MEK-1 kinase in complex with UCB1353770 and AMPPNP
Class: transferase/transferase inhibitor
Keywords: Serine-threonine kinase, Signalling, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on
2011-06-25, released
2012-02-29
The last revision prior to the SCOPe 2.03 freeze date was dated
2012-02-29, with a file datestamp of
2012-02-24.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.21
AEROSPACI score: 0.35
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Dual specificity mitogen-activated protein kinase kinase 1
Species: Homo sapiens [TaxId:9606]
Gene: Human MEK-1 kinase, MAP2K1, MEK1, PRKMK1
Database cross-references and differences (RAF-indexed):
- Uniprot Q02750 (3-303)
- expression tag (0-2)
- insertion (222)
Domains in SCOPe 2.03: d3slsa_ - Chain 'B':
Compound: Dual specificity mitogen-activated protein kinase kinase 1
Species: Homo sapiens [TaxId:9606]
Gene: Human MEK-1 kinase, MAP2K1, MEK1, PRKMK1
Database cross-references and differences (RAF-indexed):
- Uniprot Q02750 (3-303)
- expression tag (0-2)
- insertion (222)
- insertion (227)
Domains in SCOPe 2.03: d3slsb_ - Heterogens: ANP, MG, 77D, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3slsA (A:)
mtlqqrkrleafltqkqkvgelkdddfekiselgagnggvvfkvshkpsglvmarklihl
eikpairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqvlkkagri
peqilgkvsiavikgltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlidsman
sfvgtrsymsperlqgthysvqsdiwsmglslvemavgrypigsgsgsmaifelldyivn
epppklpsgvfslefqdfvnkcliknpaeradlkqlmvhafikrsdaeevdfagwlcsti
glnq
Sequence, based on observed residues (ATOM records): (download)
>3slsA (A:)
mtlqqrkrleafltqkqkvgelkdddfekiselgagnggvvfkvshkpsglvmarklihl
eikpairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqvlkkagri
peqilgkvsiavikgltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlifvgtr
symsperlqgthysvqsdiwsmglslvemavgrypigaifelldyivnepppklpsgvfs
lefqdfvnkcliknpaeradlkqlmvhafikrsdaeevdfagwlcstiglnq
- Chain 'B':
Sequence, based on SEQRES records: (download)
>3slsB (B:)
mtlqqrkrleafltqkqkvgelkdddfekiselgagnggvvfkvshkpsglvmarklihl
eikpairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqvlkkagri
peqilgkvsiavikgltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlidsman
sfvgtrsymsperlqgthysvqsdiwsmglslvemavgrypigsgsgsmaifelldyivn
epppklpsgvfslefqdfvnkcliknpaeradlkqlmvhafikrsdaeevdfagwlcsti
glnq
Sequence, based on observed residues (ATOM records): (download)
>3slsB (B:)
mtlqqrkrleafltqkqkvgelkdddfekiselgagnggvvfkvshkpsglvmarklihl
eikpairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqvlkkagri
peqilgkvsiavikgltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlidfvgt
rsymsperlqgthysvqsdiwsmglslvemavgrypigsmaifelldyivnepppklpsg
vfslefqdfvnkcliknpaeradlkqlmvhafikrsdaeevdfagwlcstiglnq