PDB entry 3sj3

View 3sj3 on RCSB PDB site
Description: Crystal structure of the mutant R160A.Y206F of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with the inhibitor BMP
Class: lyase/lyase inhibitor
Keywords: tim barrel, lyase-lyase inhibitor complex
Deposited on 2011-06-20, released 2011-06-29
The last revision prior to the SCOPe 2.06 freeze date was dated 2013-06-19, with a file datestamp of 2013-06-14.
Experiment type: XRAY
Resolution: 1.26 Å
R-factor: 0.177
AEROSPACI score: 0.77 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: orotidine 5'-phosphate decarboxylase
    Species: METHANOTHERMOBACTER THERMAUTOTROPHICUS [TaxId:187420]
    Gene: pyrF, MTH_129
    Database cross-references and differences (RAF-indexed):
    • Uniprot O26232
      • conflict (100)
      • engineered mutation (159)
      • engineered mutation (205)
    Domains in SCOPe 2.06: d3sj3a_
  • Chain 'B':
    Compound: orotidine 5'-phosphate decarboxylase
    Species: METHANOTHERMOBACTER THERMAUTOTROPHICUS [TaxId:187420]
    Gene: pyrF, MTH_129
    Database cross-references and differences (RAF-indexed):
    • Uniprot O26232
      • conflict (100)
      • engineered mutation (159)
      • engineered mutation (205)
    Domains in SCOPe 2.06: d3sj3b_
  • Heterogens: BMP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3sj3A (A:)
mrsrrvdvmdvmnrlilamdlmnrddalrvtgevreyidtvkigyplvlsegmdiiaefr
krfgcriiadfkvadipetnekicratfkagadaiivhgfpgadsvraclnvaeemgrev
flltemshpgaemfiqgaadeiarmgvdlgvknyvgpstaperlsrlreiigqdsflisp
gvgaqggdpgetlrfadaiivgrsifladnpaaaaagiiesikdllnp

    Sequence, based on observed residues (ATOM records): (download) 
    >3sj3A (A:)
dvmdvmnrlilamdlmnrddalrvtgevreyidtvkigyplvlsegmdiiaefrkrfgcr
iiadfkvadipetnekicratfkagadaiivhgfpgadsvraclnvaeemgrevflltem
shpgaemfiqgaadeiarmgvdlgvknyvgpstaperlsrlreiigqdsflispgvgaqg
gdpgetlrfadaiivgrsifladnpaaaaagiiesikdll

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3sj3B (B:)
mrsrrvdvmdvmnrlilamdlmnrddalrvtgevreyidtvkigyplvlsegmdiiaefr
krfgcriiadfkvadipetnekicratfkagadaiivhgfpgadsvraclnvaeemgrev
flltemshpgaemfiqgaadeiarmgvdlgvknyvgpstaperlsrlreiigqdsflisp
gvgaqggdpgetlrfadaiivgrsifladnpaaaaagiiesikdllnp

    Sequence, based on observed residues (ATOM records): (download) 
    >3sj3B (B:)
mdvmnrlilamdlmnrddalrvtgevreyidtvkigyplvlsegmdiiaefrkrfgcrii
adfkvadipetnekicratfkagadaiivhgfpgadsvraclnvaeemgrevflltemsh
pgaemfiqgaadeiarmgvdlgvknyvgpstaperlsrlreiigqdsflispgvgaqggd
pgetlrfadaiivgrsifladnpaaaaagiiesikdll