PDB entry 3sh1

View 3sh1 on RCSB PDB site
Description: Ac-AChBP ligand binding domain mutated to human alpha-7 nAChR
Class: receptor
Keywords: Human nicotinic acetylcholine receptor binding protein, Methyllycaconitine Binding, Glycosylation, RECEPTOR
Deposited on 2011-06-15, released 2011-10-26
The last revision prior to the SCOPe 2.05 freeze date was dated 2013-07-17, with a file datestamp of 2013-07-12.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: 0.214
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Soluble acetylcholine receptor
    Species: Aplysia californica [TaxId:6500]
    Gene: LOC100533247 soluble acetylcholine receptor
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8WSF8 (9-End)
      • expression tag (3-8)
      • engineered mutation (40)
      • engineered mutation (42)
      • engineered mutation (44)
      • engineered mutation (46)
      • engineered mutation (63)
      • engineered mutation (67)
      • engineered mutation (114)
      • engineered mutation (116)
      • engineered mutation (118-120)
      • engineered mutation (122)
      • engineered mutation (124-126)
      • engineered mutation (156)
      • engineered mutation (158)
      • engineered mutation (160)
      • engineered mutation (192-195)
      • engineered mutation (197)
      • engineered mutation (200)
      • engineered mutation (204)
    Domains in SCOPe 2.05: d3sh1a_
  • Chain 'B':
    Compound: Soluble acetylcholine receptor
    Species: Aplysia californica [TaxId:6500]
    Gene: LOC100533247 soluble acetylcholine receptor
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8WSF8 (9-End)
      • expression tag (2-8)
      • engineered mutation (40)
      • engineered mutation (42)
      • engineered mutation (44)
      • engineered mutation (46)
      • engineered mutation (63)
      • engineered mutation (67)
      • engineered mutation (114)
      • engineered mutation (116)
      • engineered mutation (118-120)
      • engineered mutation (122)
      • engineered mutation (124-126)
      • engineered mutation (156)
      • engineered mutation (158)
      • engineered mutation (160)
      • engineered mutation (192-195)
      • engineered mutation (197)
      • engineered mutation (200)
      • engineered mutation (204)
    Domains in SCOPe 2.05: d3sh1b_
  • Chain 'C':
    Compound: Soluble acetylcholine receptor
    Species: Aplysia californica [TaxId:6500]
    Gene: LOC100533247 soluble acetylcholine receptor
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8WSF8 (9-End)
      • expression tag (2-8)
      • engineered mutation (40)
      • engineered mutation (42)
      • engineered mutation (44)
      • engineered mutation (46)
      • engineered mutation (63)
      • engineered mutation (67)
      • engineered mutation (114)
      • engineered mutation (116)
      • engineered mutation (118-120)
      • engineered mutation (122)
      • engineered mutation (124-126)
      • engineered mutation (156)
      • engineered mutation (158)
      • engineered mutation (160)
      • engineered mutation (192-195)
      • engineered mutation (197)
      • engineered mutation (200)
      • engineered mutation (204)
    Domains in SCOPe 2.05: d3sh1c_
  • Chain 'D':
    Compound: Soluble acetylcholine receptor
    Species: Aplysia californica [TaxId:6500]
    Gene: LOC100533247 soluble acetylcholine receptor
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8WSF8 (9-End)
      • expression tag (2-8)
      • engineered mutation (40)
      • engineered mutation (42)
      • engineered mutation (44)
      • engineered mutation (46)
      • engineered mutation (63)
      • engineered mutation (67)
      • engineered mutation (114)
      • engineered mutation (116)
      • engineered mutation (118-120)
      • engineered mutation (122)
      • engineered mutation (124-126)
      • engineered mutation (156)
      • engineered mutation (158)
      • engineered mutation (160)
      • engineered mutation (192-195)
      • engineered mutation (197)
      • engineered mutation (200)
      • engineered mutation (204)
    Domains in SCOPe 2.05: d3sh1d_
  • Chain 'E':
    Compound: Soluble acetylcholine receptor
    Species: Aplysia californica [TaxId:6500]
    Gene: LOC100533247 soluble acetylcholine receptor
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8WSF8 (9-End)
      • expression tag (2-8)
      • engineered mutation (40)
      • engineered mutation (42)
      • engineered mutation (44)
      • engineered mutation (46)
      • engineered mutation (63)
      • engineered mutation (67)
      • engineered mutation (114)
      • engineered mutation (116)
      • engineered mutation (118-120)
      • engineered mutation (122)
      • engineered mutation (124-126)
      • engineered mutation (156)
      • engineered mutation (158)
      • engineered mutation (160)
      • engineered mutation (192-195)
      • engineered mutation (197)
      • engineered mutation (200)
      • engineered mutation (204)
    Domains in SCOPe 2.05: d3sh1e_
  • Chain 'F':
    Compound: Soluble acetylcholine receptor
    Species: Aplysia californica [TaxId:6500]
    Gene: LOC100533247 soluble acetylcholine receptor
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8WSF8 (9-End)
      • expression tag (2-8)
      • engineered mutation (40)
      • engineered mutation (42)
      • engineered mutation (44)
      • engineered mutation (46)
      • engineered mutation (63)
      • engineered mutation (67)
      • engineered mutation (114)
      • engineered mutation (116)
      • engineered mutation (118-120)
      • engineered mutation (122)
      • engineered mutation (124-126)
      • engineered mutation (156)
      • engineered mutation (158)
      • engineered mutation (160)
      • engineered mutation (192-195)
      • engineered mutation (197)
      • engineered mutation (200)
      • engineered mutation (204)
    Domains in SCOPe 2.05: d3sh1f_
  • Chain 'G':
    Compound: Soluble acetylcholine receptor
    Species: Aplysia californica [TaxId:6500]
    Gene: LOC100533247 soluble acetylcholine receptor
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8WSF8 (9-End)
      • expression tag (2-8)
      • engineered mutation (40)
      • engineered mutation (42)
      • engineered mutation (44)
      • engineered mutation (46)
      • engineered mutation (63)
      • engineered mutation (67)
      • engineered mutation (114)
      • engineered mutation (116)
      • engineered mutation (118-120)
      • engineered mutation (122)
      • engineered mutation (124-126)
      • engineered mutation (156)
      • engineered mutation (158)
      • engineered mutation (160)
      • engineered mutation (192-195)
      • engineered mutation (197)
      • engineered mutation (200)
      • engineered mutation (204)
    Domains in SCOPe 2.05: d3sh1g_
  • Chain 'H':
    Compound: Soluble acetylcholine receptor
    Species: Aplysia californica [TaxId:6500]
    Gene: LOC100533247 soluble acetylcholine receptor
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8WSF8 (9-End)
      • expression tag (2-8)
      • engineered mutation (40)
      • engineered mutation (42)
      • engineered mutation (44)
      • engineered mutation (46)
      • engineered mutation (63)
      • engineered mutation (67)
      • engineered mutation (114)
      • engineered mutation (116)
      • engineered mutation (118-120)
      • engineered mutation (122)
      • engineered mutation (124-126)
      • engineered mutation (156)
      • engineered mutation (158)
      • engineered mutation (160)
      • engineered mutation (192-195)
      • engineered mutation (197)
      • engineered mutation (200)
      • engineered mutation (204)
    Domains in SCOPe 2.05: d3sh1h_
  • Chain 'I':
    Compound: Soluble acetylcholine receptor
    Species: Aplysia californica [TaxId:6500]
    Gene: LOC100533247 soluble acetylcholine receptor
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8WSF8 (9-End)
      • expression tag (3-8)
      • engineered mutation (40)
      • engineered mutation (42)
      • engineered mutation (44)
      • engineered mutation (46)
      • engineered mutation (63)
      • engineered mutation (67)
      • engineered mutation (114)
      • engineered mutation (116)
      • engineered mutation (118-120)
      • engineered mutation (122)
      • engineered mutation (124-126)
      • engineered mutation (156)
      • engineered mutation (158)
      • engineered mutation (160)
      • engineered mutation (192-195)
      • engineered mutation (197)
      • engineered mutation (200)
      • engineered mutation (204)
    Domains in SCOPe 2.05: d3sh1i_
  • Chain 'J':
    Compound: Soluble acetylcholine receptor
    Species: Aplysia californica [TaxId:6500]
    Gene: LOC100533247 soluble acetylcholine receptor
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8WSF8 (9-End)
      • expression tag (2-8)
      • engineered mutation (40)
      • engineered mutation (42)
      • engineered mutation (44)
      • engineered mutation (46)
      • engineered mutation (63)
      • engineered mutation (67)
      • engineered mutation (114)
      • engineered mutation (116)
      • engineered mutation (118-120)
      • engineered mutation (122)
      • engineered mutation (124-126)
      • engineered mutation (156)
      • engineered mutation (158)
      • engineered mutation (160)
      • engineered mutation (192-195)
      • engineered mutation (197)
      • engineered mutation (200)
      • engineered mutation (204)
    Domains in SCOPe 2.05: d3sh1j_
  • Heterogens: MG, MLK, MRD, MPD, NAG, ACT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3sh1A (A:)
dykddddklhsqanlmrlksdlfnrspmypgptkddpltvylsfslldivkadsstnevd
lvyweqqswklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqnalvns
sghvqylpaqrlsfmcdptgvdseegatcavkfgswsyggweidlktdtdqvdlssyyas
skyeilsatqtrserfyecckepypdvnlvvkfrerragngffrnlfdsr

    Sequence, based on observed residues (ATOM records): (download) 
    >3sh1A (A:)
ddddklhsqanlmrlksdlfnrspmypgptkddpltvylsfslldivkadsstnevdlvy
weqqswklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqnalvnssgh
vqylpaqrlsfmcdptgvdseegatcavkfgswsyggweidlktdtdqvdlssyyassky
eilsatqtrserfyecckepypdvnlvvkfrerr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3sh1B (B:)
dykddddklhsqanlmrlksdlfnrspmypgptkddpltvylsfslldivkadsstnevd
lvyweqqswklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqnalvns
sghvqylpaqrlsfmcdptgvdseegatcavkfgswsyggweidlktdtdqvdlssyyas
skyeilsatqtrserfyecckepypdvnlvvkfrerragngffrnlfdsr

    Sequence, based on observed residues (ATOM records): (download) 
    >3sh1B (B:)
kddddklhsqanlmrlksdlfnrspmypgptkddpltvylsfslldivkadsstnevdlv
yweqqswklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqnalvnssg
hvqylpaqrlsfmcdptgvdseegatcavkfgswsyggweidlktdtdqvdlssyyassk
yeilsatqtrserfyecckepypdvnlvvkfrerr

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3sh1C (C:)
dykddddklhsqanlmrlksdlfnrspmypgptkddpltvylsfslldivkadsstnevd
lvyweqqswklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqnalvns
sghvqylpaqrlsfmcdptgvdseegatcavkfgswsyggweidlktdtdqvdlssyyas
skyeilsatqtrserfyecckepypdvnlvvkfrerragngffrnlfdsr

    Sequence, based on observed residues (ATOM records): (download) 
    >3sh1C (C:)
kddddklhsqanlmrlksdlfnrspmypgptkddpltvylsfslldivkadsstnevdlv
yweqqswklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqnalvnssg
hvqylpaqrlsfmcdptgvdseegatcavkfgswsyggweidlktdtdqvdlssyyassk
yeilsatqtrserfyecckepypdvnlvvkfrerra

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3sh1D (D:)
dykddddklhsqanlmrlksdlfnrspmypgptkddpltvylsfslldivkadsstnevd
lvyweqqswklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqnalvns
sghvqylpaqrlsfmcdptgvdseegatcavkfgswsyggweidlktdtdqvdlssyyas
skyeilsatqtrserfyecckepypdvnlvvkfrerragngffrnlfdsr

    Sequence, based on observed residues (ATOM records): (download) 
    >3sh1D (D:)
kddddklhsqanlmrlksdlfnrspmypgptkddpltvylsfslldivkadsstnevdlv
yweqqswklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqnalvnssg
hvqylpaqrlsfmcdptgvdseegatcavkfgswsyggweidlktdtdqvdlssyyassk
yeilsatqtrserfyecckepypdvnlvvkfrer

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >3sh1E (E:)
dykddddklhsqanlmrlksdlfnrspmypgptkddpltvylsfslldivkadsstnevd
lvyweqqswklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqnalvns
sghvqylpaqrlsfmcdptgvdseegatcavkfgswsyggweidlktdtdqvdlssyyas
skyeilsatqtrserfyecckepypdvnlvvkfrerragngffrnlfdsr

    Sequence, based on observed residues (ATOM records): (download) 
    >3sh1E (E:)
kddddklhsqanlmrlksdlfnrspmypgptkddpltvylsfslldivkadsstnevdlv
yweqqswklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqnalvnssg
hvqylpaqrlsfmcdptgvdseegatcavkfgswsyggweidlktdtdqvdlssyyassk
yeilsatqtrserfyecckepypdvnlvvkfrerr

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >3sh1F (F:)
dykddddklhsqanlmrlksdlfnrspmypgptkddpltvylsfslldivkadsstnevd
lvyweqqswklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqnalvns
sghvqylpaqrlsfmcdptgvdseegatcavkfgswsyggweidlktdtdqvdlssyyas
skyeilsatqtrserfyecckepypdvnlvvkfrerragngffrnlfdsr

    Sequence, based on observed residues (ATOM records): (download) 
    >3sh1F (F:)
kddddklhsqanlmrlksdlfnrspmypgptkddpltvylsfslldivkadsstnevdlv
yweqqswklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqnalvnssg
hvqylpaqrlsfmcdptgvdseegatcavkfgswsyggweidlktdtdqvdlssyyassk
yeilsatqtrserfyecckepypdvnlvvkfrer

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >3sh1G (G:)
dykddddklhsqanlmrlksdlfnrspmypgptkddpltvylsfslldivkadsstnevd
lvyweqqswklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqnalvns
sghvqylpaqrlsfmcdptgvdseegatcavkfgswsyggweidlktdtdqvdlssyyas
skyeilsatqtrserfyecckepypdvnlvvkfrerragngffrnlfdsr

    Sequence, based on observed residues (ATOM records): (download) 
    >3sh1G (G:)
kddddklhsqanlmrlksdlfnrspmypgptkddpltvylsfslldivkadsstnevdlv
yweqqswklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqnalvnssg
hvqylpaqrlsfmcdptgvdseegatcavkfgswsyggweidlktdtdqvdlssyyassk
yeilsatqtrserfyecckepypdvnlvvkfrer

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >3sh1H (H:)
dykddddklhsqanlmrlksdlfnrspmypgptkddpltvylsfslldivkadsstnevd
lvyweqqswklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqnalvns
sghvqylpaqrlsfmcdptgvdseegatcavkfgswsyggweidlktdtdqvdlssyyas
skyeilsatqtrserfyecckepypdvnlvvkfrerragngffrnlfdsr

    Sequence, based on observed residues (ATOM records): (download) 
    >3sh1H (H:)
kddddklhsqanlmrlksdlfnrspmypgptkddpltvylsfslldivkadsstnevdlv
yweqqswklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqnalvnssg
hvqylpaqrlsfmcdptgvdseegatcavkfgswsyggweidlktdtdqvdlssyyassk
yeilsatqtrserfyecckepypdvnlvvkfrerr

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >3sh1I (I:)
dykddddklhsqanlmrlksdlfnrspmypgptkddpltvylsfslldivkadsstnevd
lvyweqqswklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqnalvns
sghvqylpaqrlsfmcdptgvdseegatcavkfgswsyggweidlktdtdqvdlssyyas
skyeilsatqtrserfyecckepypdvnlvvkfrerragngffrnlfdsr

    Sequence, based on observed residues (ATOM records): (download) 
    >3sh1I (I:)
ddddklhsqanlmrlksdlfnrspmypgptkddpltvylsfslldivkadsstnevdlvy
weqqswklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqnalvnssgh
vqylpaqrlsfmcdptgvdseegatcavkfgswsyggweidlktdtdqvdlssyyassky
eilsatqtrserfyecckepypdvnlvvkfrerr

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >3sh1J (J:)
dykddddklhsqanlmrlksdlfnrspmypgptkddpltvylsfslldivkadsstnevd
lvyweqqswklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqnalvns
sghvqylpaqrlsfmcdptgvdseegatcavkfgswsyggweidlktdtdqvdlssyyas
skyeilsatqtrserfyecckepypdvnlvvkfrerragngffrnlfdsr

    Sequence, based on observed residues (ATOM records): (download) 
    >3sh1J (J:)
kddddklhsqanlmrlksdlfnrspmypgptkddpltvylsfslldivkadsstnevdlv
yweqqswklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqnalvnssg
hvqylpaqrlsfmcdptgvdseegatcavkfgswsyggweidlktdtdqvdlssyyassk
yeilsatqtrserfyecckepypdvnlvvkfrerr