PDB entry 3sgk

View 3sgk on RCSB PDB site
Description: Unique carbohydrate/carbohydrate interactions are required for high affinity binding of FcgIII and antibodies lacking core fucose
Class: immune system
Keywords: Fc receptor, antibody, afucosylation, IMMUNE SYSTEM
Deposited on 2011-06-15, released 2011-08-03
The last revision prior to the SCOPe 2.06 freeze date was dated 2012-04-04, with a file datestamp of 2012-03-30.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.207
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: fc fragment
    Species: Homo sapiens [TaxId:9606]
    Gene: IGHG1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3sgka1, d3sgka2
  • Chain 'B':
    Compound: fc fragment
    Species: Homo sapiens [TaxId:9606]
    Gene: IGHG1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3sgkb1, d3sgkb2
  • Chain 'C':
    Compound: human Fcg3a receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: FCGR3A, CD16A, FCG3, FCGR3, IGFR3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08637
      • engineered mutation (37)
      • engineered mutation (73)
      • see remark 999 (157)
      • engineered mutation (168)
    Domains in SCOPe 2.06: d3sgkc1, d3sgkc2
  • Heterogens: MLI, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3sgkA (A:)
    thtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgv
    evhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgq
    prepqvytlppsrdeltknqvsltclvkgfypsdiavewesngqpennykttppvldsdg
    sfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslspgk
    

    Sequence, based on observed residues (ATOM records): (download)
    >3sgkA (A:)
    ggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeq
    ynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqprepqvytlppsr
    deltknqvsltclvkgfypsdiavewesngqpennykttppvldsdgsfflyskltvdks
    rwqqgnvfscsvmhealhnhytqkslsls
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >3sgkB (B:)
    thtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgv
    evhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgq
    prepqvytlppsrdeltknqvsltclvkgfypsdiavewesngqpennykttppvldsdg
    sfflyskltvdksrwqqgnvfscsvmhealhnhytqkslslspgk
    

    Sequence, based on observed residues (ATOM records): (download)
    >3sgkB (B:)
    pellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkp
    reeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqprepqvytl
    ppsrdeltknqvsltclvkgfypsdiavewesngqpennykttppvldsdgsfflysklt
    vdksrwqqgnvfscsvmhealhnhytqkslsl
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >3sgkC (C:)
    rtedlpkavvflepqwyrvlekdsvtlkcqgayspedqstqwfhneslissqassyfida
    atvddsgeyrcqtqlstlsdpvqlevhigwlllqaprwvfkeedpihlrchswkntalhk
    vtylqngkgrkyfhhnsdfyipkatlkdsgsyfcrglvgsknvssetvqititqglavst
    issffppgyqgkkkkkkghhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >3sgkC (C:)
    lpkavvflepqwyrvlekdsvtlkcqgaqstqwfhneslissqassyfidaatvddsgey
    rcqtqlstlsdpvqlevhigwlllqaprwvfkeedpihlrchswkntalhkvtylqngkg
    rkyfhhnsdfyipkatlkdsgsyfcrglvgsknvssetvqititq