PDB entry 3sfx

View 3sfx on RCSB PDB site
Description: Cryptococcus neoformans protein farnesyltransferase in complex with FPT-II and tipifarnib
Class: transferase/transferase inhibitor
Keywords: prenyltransferase, protein farnesyltransferase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2011-06-14, released 2011-08-03
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-10-19, with a file datestamp of 2011-10-14.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.181
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cryptococcus neoformans protein farnesyltransferase alpha subunit
    Species: Cryptococcus neoformans [TaxId:235443]
    Database cross-references and differences (RAF-indexed):
    • PDB 3SFX
    Domains in SCOPe 2.07: d3sfxa_
  • Chain 'B':
    Compound: Cryptococcus neoformans protein farnesyltransferase beta subunit
    Species: Cryptococcus neoformans [TaxId:235443]
    Database cross-references and differences (RAF-indexed):
    • PDB 3SFX
  • Heterogens: ZN, 3FX, FII, JAN, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3sfxA (A:)
    mgsshhhhhhsqlmvtstyipmsqrrswadvkpimqddgpnpvvpimyseeykdamdyfr
    aiaakeekseralelteiivrmnpahytvwqyrfslltslnksledelrlmnefavqnlk
    syqvwhhrlllldrispqdpvseieyihgsllpdpknyhtwaylhwlyshfstlgrisea
    qwgseldwcnemlrvdgrnnsawgwrwylrvsrpgaetssrslqdeliyilksihliphn
    vsawnylrgflkhfslplvpilpailpytasklnpdietveafgfpmpsdplpedtplpv
    plaleyladsfieqnrvddaakvfeklsseydqmragywefrrrecaee
    

    Sequence, based on observed residues (ATOM records): (download)
    >3sfxA (A:)
    tyipmsqrrswadvkpimqddgpnpvvpimyseeykdamdyfraiaakeekseralelte
    iivrmnpahytvwqyrfslltslnksledelrlmnefavqnlksyqvwhhrlllldrisp
    qdpvseieyihgsllpdpknyhtwaylhwlyshfstlgriseaqwgseldwcnemlrvdg
    rnnsawgwrwylrvsrpgaetssrslqdeliyilksihliphnvsawnylrgflkhfslp
    lvpilpailpytafpmpsplpedtplpvplaleyladsfieqnrvddaakvfeklsseyd
    qmragywefrrreca
    

  • Chain 'B':
    No sequence available.