PDB entry 3sfk

View 3sfk on RCSB PDB site
Description: Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM267
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: alpha beta fold, pyrimidine biosynthesis, flavoprotein, mitochondrion inner membrane, alpha beta barrel oxidoreductase, inhibitor DSM267, FMN, Plasmodium falciparum membrane mitochondrion, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Deposited on 2011-06-13, released 2011-07-06
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-08-17, with a file datestamp of 2011-08-12.
Experiment type: XRAY
Resolution: 2.95 Å
R-factor: 0.227
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dihydroorotate dehydrogenase (quinone), mitochondrial
    Species: Plasmodium falciparum 3D7 [TaxId:36329]
    Gene: PFF0160c
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3sfka_
  • Heterogens: D67, FMN, ORO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3sfkA (A:)
mghhhhhhaenlyfqgapfesynpefflydiflkfclkyidgeichdlflllgkynilpy
dtsndsiyactnikhldfinpfgvaagfdkngvcidsilklgfsfieigtitprgqtgna
kprifrdvesrsiinscgfnnmgcdkvtenlilfrkrqeedkllskhivgvsigknkdtv
nivddlkycinkigryadyiainvsspntpglrdnqeagklkniilsvkeeidnleknni
mndeflwfnttkkkplvfvklapdlnqeqkkeiadvlletnidgmiisntttqindiksf
enkkggvsgaklkdistkficemynytnkqipiiasggifsgldalekieagasvcqlys
clvfngmksavqikrelnhllyqrgyynlkeaigrkhsks

    Sequence, based on observed residues (ATOM records): (download) 
    >3sfkA (A:)
ynpefflydiflkfclkyidgeichdlflllgkynilpydtsndsiyactnikhldfinp
fgvaagfdkngvcidsilklgfsfieigtitprgqtgnakprifrdvesrsiinscgfnn
mgcdkvtenlilfrkrqeedkllskhivgvsigknkdtvnivddlkycinkigryadyia
invsspnqeagklkniilsvkeeidnleknnimndeflwfnttkkkplvfvklapdlnqe
qkkeiadvlletnidgmiisntttqindiksfenkkggvsgaklkdistkficemynytn
kqipiiasggifsgldalekieagasvcqlysclvfngmksavqikrelnhllyqrgyyn
lkeaigrk