PDB entry 3sfi
View 3sfi on RCSB PDB site
Description: Ethionamide Boosters Part 2: Combining Bioisosteric Replacement and Structure-Based Drug Design to Solve Pharmacokinetic Issues in a Series of Potent 1,2,4-Oxadiazole EthR Inhibitors.
Class: transcription repressor/inhibitor
Keywords: TETR-FAMILY, TRANSCRITPTIONAL REGULATORY REPRESSOR, INHIBITOR, DNA, DNA BINDING PROTEIN, TRANSCRIPTION REPRESSOR-INHIBITOR complex
Deposited on
2011-06-13, released
2011-12-07
The last revision prior to the SCOPe 2.08 freeze date was dated
2018-01-24, with a file datestamp of
2018-01-19.
Experiment type: XRAY
Resolution: 2.31 Å
R-factor: N/A
AEROSPACI score: 0.24
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Transcriptional regulatory repressor protein (TETR-family)
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: ethR, MT3970, Rv3855
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d3sfia1, d3sfia2 - Heterogens: 3SF, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3sfiA (A:)
mgsshhhhhhssglvprgshmttsaasqaslprgrrtarpsgddrelailataenlledr
pladisvddlakgagisrptfyfyfpskeavlltlldrvvnqadmalqtlaenpadtdre
nmwrtginvffetfgshkavtragqaaratsvevaelwstfmqkwiaytaavidaerdrg
aaprtlpahelatalnlmnertlfasfageqpsvpearvldtlvhiwvtsiygenr
Sequence, based on observed residues (ATOM records): (download)
>3sfiA (A:)
gddrelailataenlledrpladisvddlakgagisrptfyfyfpskeavlltlldrvvn
qadmalqtlaenpadtdrenmwrtginvffetfgshkavtragqaaratsvevaelwstf
mqkwiaytaavidaerdrgaaprtlpahelatalnlmnertlfasfageqpsvpearvld
tlvhiwvtsiyge