PDB entry 3saz

View 3saz on RCSB PDB site
Description: Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 4-(3-bromophenyl)-2,4-dioxobutanoic acid inhibitor
Class: transferase/transferase inhibitor
Keywords: inhibitor complex, Structural Genomics, Mycobacterium Tuberculosis Structural Proteomics Project, XMTB, malate synthase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2011-06-03, released 2012-11-07
The last revision prior to the SCOPe 2.06 freeze date was dated 2013-02-20, with a file datestamp of 2013-02-15.
Experiment type: XRAY
Resolution: 2.04 Å
R-factor: 0.165
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: malate synthase g
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: glcB, GlcB (Rv1837c), MT1885, MTCY1A11.06, Rv1837c
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0A5J4
      • engineered mutation (618)
    Domains in SCOPe 2.06: d3saza_
  • Heterogens: 043, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3sazA (A:)
mtdrvsvgnlriarvlydfvnnealpgtdidpdsfwagvdkvvadltpqnqallnardel
qaqidkwhrrrviepidmdayrqflteigyllpepddftittsgvdaeitttagpqlvvp
vlnarfalnaanarwgslydalygtdvipetdgaekgptynkvrgdkviayarkflddsv
plssgsfgdatgftvqdgqlvvalpdkstglanpgqfagytgaaesptsvllinhglhie
ilidpesqvgttdragvkdvilesaittimdfedsvaavdaadkvlgyrnwlglnkgdla
aavdkdgtaflrvlnrdrnytapgggqftlpgrslmfvrnvghlmtndaivdtdgsevfe
gimdalftgliaihglkasdvngplinsrtgsiyivkpkmhgpaevaftcelfsrvedvl
glpqntmkigimdeerrttvnlkacikaaadrvvfintgfldrtgdeihtsmeagpmvrk
gtmksqpwilayedhnvdaglaagfsgraqvgkgmwtmtelmadmvetkiaqpragasta
wvpsptaatlhalhyhqvdvaavqqglagkrratieqlltiplakelawapdeireevdn
ncqsilgyvvrwvdqgvgaskvpdihdvalmedratlrissqllanwlrhgvitsadvra
slermaplvdrqnagdvayrpmapnfddsiaflaaqelilsgaqqpngytepilhrrrre
fkaraaekpapsdragddaar

    Sequence, based on observed residues (ATOM records): (download) 
    >3sazA (A:)
tdrvsvgnlriarvlydfvnnealpgtdidpdsfwagvdkvvadltpqnqallnardelq
aqidkwhrrrviepidmdayrqflteigyllpepddftittsgvdaeitttagpqlvvpv
lnarfalnaanarwgslydalygtdvipetdgaekgptynkvrgdkviayarkflddsvp
lssgsfgdatgftvqdgqlvvalpdkstglanpgqfagytgaaesptsvllinhglhiei
lidpesqvgttdragvkdvilesaittimdfedsvaavdaadkvlgyrnwlglnkgdlaa
flrvlnrdrnytapgggqftlpgrslmfvrnvghlmtndaivdtdgsevfegimdalftg
liaihglkasdlinsrtgsiyivkpkmhgpaevaftcelfsrvedvlglpqntmkigimd
eerrttvnlkacikaaadrvvfintgfldrtgdeihtsmeagpmvrkgtmksqpwilaye
dhnvdaglaagfsgraqvgkgmwtmtelmadmvetkiaqpragastawvpsptaatlhal
hyhqvdvaavqqglagkrratieqlltiplakelawapdeireevdnncqsilgyvvrwv
dqgvgaskvpdihdvalmedratlrissqllanwlrhgvitsadvraslermaplvdrqn
avayrpmapnfddsiaflaaqelilsgaqqpngytepilhrrrrefkaraae