PDB entry 3s8e

View 3s8e on RCSB PDB site
Description: Phosphorylation regulates assembly of the caspase-6 substrate-binding groove
Class: hydrolase
Keywords: phosphomimetic, caspase, apoptosis, zymogen, hydrolase, Huntington's, Alzheimer's, cancer, Protease, cytosol
Deposited on 2011-05-27, released 2012-04-11
The last revision prior to the SCOPe 2.03 freeze date was dated 2013-07-10, with a file datestamp of 2013-07-05.
Experiment type: XRAY
Resolution: 2.88 Å
R-factor: 0.218
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Caspase-6
    Species: Homo sapiens [TaxId:9606]
    Gene: CASP6, MCH2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P55212
      • engineered mutation (234)
    Domains in SCOPe 2.03: d3s8ea_
  • Chain 'B':
    Compound: Caspase-6
    Species: Homo sapiens [TaxId:9606]
    Gene: CASP6, MCH2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P55212
      • engineered mutation (234)
    Domains in SCOPe 2.03: d3s8eb_
  • Chain 'C':
    Compound: Caspase-6
    Species: Homo sapiens [TaxId:9606]
    Gene: CASP6, MCH2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P55212
      • engineered mutation (234)
    Domains in SCOPe 2.03: d3s8ec_
  • Chain 'D':
    Compound: Caspase-6
    Species: Homo sapiens [TaxId:9606]
    Gene: CASP6, MCH2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P55212
      • engineered mutation (234)
    Domains in SCOPe 2.03: d3s8ed_
  • Chain 'E':
    Compound: Caspase-6
    Species: Homo sapiens [TaxId:9606]
    Gene: CASP6, MCH2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P55212
      • engineered mutation (234)
    Domains in SCOPe 2.03: d3s8ee_
  • Chain 'F':
    Compound: Caspase-6
    Species: Homo sapiens [TaxId:9606]
    Gene: CASP6, MCH2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P55212
      • engineered mutation (234)
    Domains in SCOPe 2.03: d3s8ef_
  • Chain 'G':
    Compound: Caspase-6
    Species: Homo sapiens [TaxId:9606]
    Gene: CASP6, MCH2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P55212
      • engineered mutation (234)
    Domains in SCOPe 2.03: d3s8eg_
  • Chain 'H':
    Compound: Caspase-6
    Species: Homo sapiens [TaxId:9606]
    Gene: CASP6, MCH2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P55212
      • engineered mutation (234)
    Domains in SCOPe 2.03: d3s8eh_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3s8eA (A:)
mafykremfdpaekykmdhrrrgialifnherffwhltlperrgtcadrdnltrrfsdlg
fevkcfndlkaeelllkihevstvshadadcfvcvflshgegnhiyaydakieiqtltgl
fkgdkchslvgkpkifiiqacrgnqhdvpvipldvvdnqtekldtnitevdaasvytlpa
gadflmcysvaegyyshretvngswyiqdlcemlgkygssleftelltlvnrkvdqrrvd
fckdpsaigkkqvpcfasmltkklhffpksnhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3s8eA (A:)
mfdpaekykmdhrrrgialifnherffwhltlperrgtcadrdnltrrfsdlgfevkcfn
dlkaeelllkihevstvshadadcfvcvflshgegnhiyaydakieiqtltglfkgdkch
slvgkpkifiiqacsvytlpagadflmcysvaetvngswyiqdlcemlgkygssleftel
ltlvnrkvdqrrvdsaigkkqvpcfasmltkklhffpks

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3s8eB (B:)
mafykremfdpaekykmdhrrrgialifnherffwhltlperrgtcadrdnltrrfsdlg
fevkcfndlkaeelllkihevstvshadadcfvcvflshgegnhiyaydakieiqtltgl
fkgdkchslvgkpkifiiqacrgnqhdvpvipldvvdnqtekldtnitevdaasvytlpa
gadflmcysvaegyyshretvngswyiqdlcemlgkygssleftelltlvnrkvdqrrvd
fckdpsaigkkqvpcfasmltkklhffpksnhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3s8eB (B:)
mfdpaekykmdhrrrgialifnherffwhltlperrgtcadrdnltrrfsdlgfevkcfn
dlkaeelllkihevstvshadadcfvcvflshgegnhiyaydakieiqtltglfkgdkch
slvgkpkifiiqacsvytlpagadflmcysvatvngswyiqdlcemlgkygssleftell
tlvnrkvdqrrvigkkqvpcfasmltkklhffpk

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3s8eC (C:)
mafykremfdpaekykmdhrrrgialifnherffwhltlperrgtcadrdnltrrfsdlg
fevkcfndlkaeelllkihevstvshadadcfvcvflshgegnhiyaydakieiqtltgl
fkgdkchslvgkpkifiiqacrgnqhdvpvipldvvdnqtekldtnitevdaasvytlpa
gadflmcysvaegyyshretvngswyiqdlcemlgkygssleftelltlvnrkvdqrrvd
fckdpsaigkkqvpcfasmltkklhffpksnhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3s8eC (C:)
mfdpaekykmdhrrrgialifnherffwhltlperrgtcadrdnltrrfsdlgfevkcfn
dlkaeelllkihevstvshadadcfvcvflshgegnhiyaydakieiqtltglfkgdkch
slvgkpkifiiqacsvytlpagadflmcysvaetvngswyiqdlcemlgkygssleftel
ltlvnrkvdqrrvdfaigkkqvpcfasmltkklhffpks

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3s8eD (D:)
mafykremfdpaekykmdhrrrgialifnherffwhltlperrgtcadrdnltrrfsdlg
fevkcfndlkaeelllkihevstvshadadcfvcvflshgegnhiyaydakieiqtltgl
fkgdkchslvgkpkifiiqacrgnqhdvpvipldvvdnqtekldtnitevdaasvytlpa
gadflmcysvaegyyshretvngswyiqdlcemlgkygssleftelltlvnrkvdqrrvd
fckdpsaigkkqvpcfasmltkklhffpksnhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3s8eD (D:)
emfdpaekykmdhrrrgialifnherffwhltlperrgtcadrdnltrrfsdlgfevkcf
ndlkaeelllkihevstvshadadcfvcvflshgegnhiyaydakieiqtltglfkgdkc
hslvgkpkifiiqacvytlpagadflmcysvaeshretvngswyiqdlcemlgkygssle
ftelltlvnrkvdqrrvsaigkkqvpcfasmltkklhffpk

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >3s8eE (E:)
mafykremfdpaekykmdhrrrgialifnherffwhltlperrgtcadrdnltrrfsdlg
fevkcfndlkaeelllkihevstvshadadcfvcvflshgegnhiyaydakieiqtltgl
fkgdkchslvgkpkifiiqacrgnqhdvpvipldvvdnqtekldtnitevdaasvytlpa
gadflmcysvaegyyshretvngswyiqdlcemlgkygssleftelltlvnrkvdqrrvd
fckdpsaigkkqvpcfasmltkklhffpksnhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3s8eE (E:)
mfdpaekykmdhrrrgialifnherffwhltlperrgtcadrdnltrrfsdlgfevkcfn
dlkaeelllkihevstvshadadcfvcvflshgegnhiyaydakieiqtltglfkgdkch
slvgkpkifiiqacsvytlpagadflmcysvaegtvngswyiqdlcemlgkygsslefte
lltlvnrkvdqrrvsaigkkqvpcfasmltkklhffpks

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >3s8eF (F:)
mafykremfdpaekykmdhrrrgialifnherffwhltlperrgtcadrdnltrrfsdlg
fevkcfndlkaeelllkihevstvshadadcfvcvflshgegnhiyaydakieiqtltgl
fkgdkchslvgkpkifiiqacrgnqhdvpvipldvvdnqtekldtnitevdaasvytlpa
gadflmcysvaegyyshretvngswyiqdlcemlgkygssleftelltlvnrkvdqrrvd
fckdpsaigkkqvpcfasmltkklhffpksnhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3s8eF (F:)
mfdpaekykmdhrrrgialifnherffwhltlperrgtcadrdnltrrfsdlgfevkcfn
dlkaeelllkihevstvshadadcfvcvflshgegnhiyaydakieiqtltglfkgdkch
slvgkpkifiiqacsvytlpagadflmcysvaetvngswyiqdlcemlgkygssleftel
ltlvnrkvdqrrvdfcpsaigkkqvpcfasmltkklhffpks

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >3s8eG (G:)
mafykremfdpaekykmdhrrrgialifnherffwhltlperrgtcadrdnltrrfsdlg
fevkcfndlkaeelllkihevstvshadadcfvcvflshgegnhiyaydakieiqtltgl
fkgdkchslvgkpkifiiqacrgnqhdvpvipldvvdnqtekldtnitevdaasvytlpa
gadflmcysvaegyyshretvngswyiqdlcemlgkygssleftelltlvnrkvdqrrvd
fckdpsaigkkqvpcfasmltkklhffpksnhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3s8eG (G:)
emfdpaekykmdhrrrgialifnherffwhltlperrgtcadrdnltrrfsdlgfevkcf
ndlkaeelllkihevstvshadadcfvcvflshgegnhiyaydakieiqtltglfkgdkc
hslvgkpkifiiqacvytlpagadflmcysvaetvngswyiqdlcemlgkygssleftel
ltlvnrkvdqrrvigkkqvpcfasmltkklhffpks

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >3s8eH (H:)
mafykremfdpaekykmdhrrrgialifnherffwhltlperrgtcadrdnltrrfsdlg
fevkcfndlkaeelllkihevstvshadadcfvcvflshgegnhiyaydakieiqtltgl
fkgdkchslvgkpkifiiqacrgnqhdvpvipldvvdnqtekldtnitevdaasvytlpa
gadflmcysvaegyyshretvngswyiqdlcemlgkygssleftelltlvnrkvdqrrvd
fckdpsaigkkqvpcfasmltkklhffpksnhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3s8eH (H:)
mfdpaekykmdhrrrgialifnherffwhltlperrgtcadrdnltrrfsdlgfevkcfn
dlkaeelllkihevstvshadadcfvcvflshgegnhiyaydakieiqtltglfkgdkch
slvgkpkifiiqacvytlpagadflmcysvhretvngswyiqdlcemlgkygssleftel
ltlvnrkvdqrrvaigkkqvpcfasmltkklhffpks