PDB entry 3ri1

View 3ri1 on RCSB PDB site
Description: Crystal structure of the catalytic domain of FGFR2 kinase in complex with ARQ 069
Class: Transferase/Transferase Inhibitor
Keywords: FGFR1 kinase, FGFR2 kinase, inactive conformation, kinase-inhibitor complex, Transferase-Transferase Inhibitor complex
Deposited on 2011-04-12, released 2011-05-04
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-10-19, with a file datestamp of 2011-10-14.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.216
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Fibroblast growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: FGFR2, BEK, KGFR, KSAM
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3ri1a_
  • Chain 'B':
    Compound: Fibroblast growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: FGFR2, BEK, KGFR, KSAM
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3ri1b_
  • Heterogens: 3RH, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3ri1A (A:)
    gspmlagvseyelpedpkwefprdkltlgkplgegcfgqvvmaeavgidkdkpkeavtva
    vkmlkddatekdlsdlvsememmkmigkhkniinllgactqdgplyviveyaskgnlrey
    lrarrppgmeysydinrvpeeqmtfkdlvsctyqlargmeylasqkcihrdlaarnvlvt
    ennvmkiadfglardinnidyykkttngrlpvkwmapealfdrvythqsdvwsfgvlmwe
    iftlggspypgipveelfkllkeghrmdkpanctnelymmmrdcwhavpsqrptfkqlve
    dldriltlttnee
    

    Sequence, based on observed residues (ATOM records): (download)
    >3ri1A (A:)
    lpedpkwefprdkltlgkplgegcfgqvvmaeavgidkdkpkeavtvavkmlkddatekd
    lsdlvsememmkmigkhkniinllgactqdgplyviveyaskgnlreylrarrppeqmtf
    kdlvsctyqlargmeylasqkcihrdlaarnvlvtennvmkiadfglardinnidyykkt
    tngrlpvkwmapealfdrvythqsdvwsfgvlmweiftlggspypgipveelfkllkegh
    rmdkpanctnelymmmrdcwhavpsqrptfkqlvedldriltltt
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >3ri1B (B:)
    gspmlagvseyelpedpkwefprdkltlgkplgegcfgqvvmaeavgidkdkpkeavtva
    vkmlkddatekdlsdlvsememmkmigkhkniinllgactqdgplyviveyaskgnlrey
    lrarrppgmeysydinrvpeeqmtfkdlvsctyqlargmeylasqkcihrdlaarnvlvt
    ennvmkiadfglardinnidyykkttngrlpvkwmapealfdrvythqsdvwsfgvlmwe
    iftlggspypgipveelfkllkeghrmdkpanctnelymmmrdcwhavpsqrptfkqlve
    dldriltlttnee
    

    Sequence, based on observed residues (ATOM records): (download)
    >3ri1B (B:)
    lpedpkwefprdkltlgkplgegcfgqvvmaeavgidpkeavtvavkmlkddatekdlsd
    lvsememmkmigkhkniinllgactqdgplyviveyaskgnlreylrarrppeqmtfkdl
    vsctyqlargmeylasqkcihrdlaarnvlvtennvmkiadfglardinnidyykkttng
    rlpvkwmapealfdrvythqsdvwsfgvlmweiftlggspypgipveelfkllkeghrmd
    kpanctnelymmmrdcwhavpsqrptfkqlvedldriltlttn