PDB entry 3rdh

View 3rdh on RCSB PDB site
Description: X-ray induced covalent inhibition of 14-3-3
Class: signaling protein/inhibitor
Keywords: phosphoSer/Thr-mimetic agent, phosphoserine/threonine-recognition protein, SIGNALING PROTEIN-INHIBITOR complex
Deposited on 2011-04-01, released 2011-09-28
The last revision prior to the SCOPe 2.01 freeze date was dated 2011-10-12, with a file datestamp of 2011-10-07.
Experiment type: XRAY
Resolution: 2.39 Å
R-factor: 0.235
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 14-3-3 protein zeta/delta
    Species: Homo sapiens [TaxId:9606]
    Gene: YWHAZ
    Database cross-references and differences (RAF-indexed):
    • Uniprot P63104 (3-End)
      • expression tag (0-2)
    Domains in SCOPe 2.01: d3rdha_
  • Chain 'B':
    Compound: 14-3-3 protein zeta/delta
    Species: Homo sapiens [TaxId:9606]
    Gene: YWHAZ
    Database cross-references and differences (RAF-indexed):
    • Uniprot P63104 (3-End)
      • expression tag (0-2)
    Domains in SCOPe 2.01: d3rdhb_
  • Chain 'C':
    Compound: 14-3-3 protein zeta/delta
    Species: Homo sapiens [TaxId:9606]
    Gene: YWHAZ
    Database cross-references and differences (RAF-indexed):
    • Uniprot P63104 (3-End)
      • expression tag (0-2)
    Domains in SCOPe 2.01: d3rdhc_
  • Chain 'D':
    Compound: 14-3-3 protein zeta/delta
    Species: Homo sapiens [TaxId:9606]
    Gene: YWHAZ
    Database cross-references and differences (RAF-indexed):
    • Uniprot P63104 (3-End)
      • expression tag (0-2)
    Domains in SCOPe 2.01: d3rdhd_
  • Heterogens: 3RD, NI, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3rdhA (A:)
gshmdknelvqkaklaeqaeryddmaacmksvteqgaelsneernllsvayknvvgarrs
swrvvssieqktegaekkqqmareyrekietelrdicndvlsllekflipnasqaeskvf
ylkmkgdyyrylaevaagddkkgivdqsqqayqeafeiskkemqpthpirlglalnfsvf
yyeilnspekacslaktafdeaiaeldtlseesykdstlimqllrdnltlwtsdtqgdea
eageggen

    Sequence, based on observed residues (ATOM records): (download) 
    >3rdhA (A:)
gshmdknelvqkaklaeqaeryddmaacmksvteqgaelsneernllsvayknvvgarrs
swrvvssieqktegaekkqqmareyrekietelrdicndvlsllekflipnasqaeskvf
ylkmkgdyyrylaevaagddkkgivdqsqqayqeafeiskkemqpthpirlglalnfsvf
yyeilnspekacslaktafdeaiaeldtlseesykdstlimqllrdnltlwts

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3rdhB (B:)
gshmdknelvqkaklaeqaeryddmaacmksvteqgaelsneernllsvayknvvgarrs
swrvvssieqktegaekkqqmareyrekietelrdicndvlsllekflipnasqaeskvf
ylkmkgdyyrylaevaagddkkgivdqsqqayqeafeiskkemqpthpirlglalnfsvf
yyeilnspekacslaktafdeaiaeldtlseesykdstlimqllrdnltlwtsdtqgdea
eageggen

    Sequence, based on observed residues (ATOM records): (download) 
    >3rdhB (B:)
gshmdknelvqkaklaeqaeryddmaacmksvteqgaelsneernllsvayknvvgarrs
swrvvssieqktegaekkqqmareyrekietelrdicndvlsllekflipnasqaeskvf
ylkmkgdyyrylaevaagddkkgivdqsqqayqeafeiskkemqpthpirlglalnfsvf
yyeilnspekacslaktafdeaiaeldtlseesykdstlimqllrdnltlwts

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3rdhC (C:)
gshmdknelvqkaklaeqaeryddmaacmksvteqgaelsneernllsvayknvvgarrs
swrvvssieqktegaekkqqmareyrekietelrdicndvlsllekflipnasqaeskvf
ylkmkgdyyrylaevaagddkkgivdqsqqayqeafeiskkemqpthpirlglalnfsvf
yyeilnspekacslaktafdeaiaeldtlseesykdstlimqllrdnltlwtsdtqgdea
eageggen

    Sequence, based on observed residues (ATOM records): (download) 
    >3rdhC (C:)
gshmdknelvqkaklaeqaeryddmaacmksvteqgaelsneernllsvayknvvgarrs
swrvvssieqktegaekkqqmareyrekietelrdicndvlsllekflipnasqaeskvf
ylkmkgdyyrylaevaagddkkgivdqsqqayqeafeiskkemqpthpirlglalnfsvf
yyeilnspekacslaktafdeaiaeldtlseesykdstlimqllrdnltlwts

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3rdhD (D:)
gshmdknelvqkaklaeqaeryddmaacmksvteqgaelsneernllsvayknvvgarrs
swrvvssieqktegaekkqqmareyrekietelrdicndvlsllekflipnasqaeskvf
ylkmkgdyyrylaevaagddkkgivdqsqqayqeafeiskkemqpthpirlglalnfsvf
yyeilnspekacslaktafdeaiaeldtlseesykdstlimqllrdnltlwtsdtqgdea
eageggen

    Sequence, based on observed residues (ATOM records): (download) 
    >3rdhD (D:)
gshmdknelvqkaklaeqaeryddmaacmksvteqgaelsneernllsvayknvvgarrs
swrvvssieqktegaekkqqmareyrekietelrdicndvlsllekflipnasqaeskvf
ylkmkgdyyrylaevaagddkkgivdqsqqayqeafeiskkemqpthpirlglalnfsvf
yyeilnspekacslaktafdeaiaeldtlseesykdstlimqllrdnltlwts