PDB entry 3r8a

View 3r8a on RCSB PDB site
Description: X-ray crystal structure of the nuclear hormone receptor PPAR-gamma in a complex with a compound with dual PPAR gamma agonism and Angiotensin II Type I receptor antagonism activity
Class: nuclear protein
Keywords: Nuclear Hormone Activator, Angiotensin II Type I Receptor Antagonist, Ligand Bound Structure, Diabetes mellitus, Metabolic Syndrome, Obesity, NUCLEAR PROTEIN
Deposited on 2011-03-23, released 2012-03-14
The last revision prior to the SCOPe 2.07 freeze date was dated 2012-03-14, with a file datestamp of 2012-03-09.
Experiment type: XRAY
Resolution: 2.41 Å
R-factor: 0.233
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Peroxisome proliferator-activated receptor gamma
    Species: Homo sapiens [TaxId:9606]
    Gene: NR1C3, PPARG
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3r8aa_
  • Chain 'B':
    Compound: Peroxisome proliferator-activated receptor gamma
    Species: Homo sapiens [TaxId:9606]
    Gene: NR1C3, PPARG
    Database cross-references and differences (RAF-indexed):
    • Uniprot P37231 (11-End)
      • expression tag (10)
    Domains in SCOPe 2.07: d3r8ab1, d3r8ab2
  • Heterogens: HIG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3r8aA (A:)
    mkkghhhhhhgesadlralakhlydsyiksfpltkakarailtgkttdkspfviydmnsl
    mmgedkikfkhitplqeqskevairifqgcqfrsveavqeiteyaksipgfvnldlndqv
    tllkygvheiiytmlaslmnkdgvlisegqgfmtreflkslrkpfgdfmepkfefavkfn
    alelddsdlaifiaviilsgdrpgllnvkpiediqdnllqalelqlklnhpessqlfakl
    lqkmtdlrqivtehvqllqvikktetdmslhpllqeiykdly
    

    Sequence, based on observed residues (ATOM records): (download)
    >3r8aA (A:)
    esadlralakhlydsyiksfpltkakarailtgkdkspfviydmnslmmgedkiskevai
    rifqgcqfrsveavqeiteyaksipgfvnldlndqvtllkygvheiiytmlaslmnkdgv
    lisegqgfmtreflkslrkpfgdfmepkfefavkfnalelddsdlaifiaviilsgdrpg
    llnvkpiediqdnllqalelqlklnhpessqlfakllqkmtdlrqivtehvqllqvikkt
    etdmslhpllq
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >3r8aB (B:)
    mkkghhhhhhgesadlralakhlydsyiksfpltkakarailtgkttdkspfviydmnsl
    mmgedkikfkhitplqeqskevairifqgcqfrsveavqeiteyaksipgfvnldlndqv
    tllkygvheiiytmlaslmnkdgvlisegqgfmtreflkslrkpfgdfmepkfefavkfn
    alelddsdlaifiaviilsgdrpgllnvkpiediqdnllqalelqlklnhpessqlfakl
    lqkmtdlrqivtehvqllqvikktetdmslhpllqeiykdly
    

    Sequence, based on observed residues (ATOM records): (download)
    >3r8aB (B:)
    gesadlralakhlydsyiksfpltkakarailtgkkspfviydmnslmmevairifqgcq
    frsveavqeiteyaksipgfvnldlndqvtllkygvheiiytmlaslmnkdgvlisegqg
    fmtreflkslrkpfgdfmepkfefavkfnalelddsdlaifiaviilsgdrpgllnvkpi
    ediqdnllqalelqlklnhpessqlfakllqkmtdlrqivtehvqllqvhpllqeiykd