PDB entry 3r58

View 3r58 on RCSB PDB site
Description: AKR1C3 complex with naproxen
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: TIM barrel, aldo-keto reductase, nitro reductase, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Deposited on 2011-03-18, released 2012-03-28
The last revision prior to the SCOPe 2.06 freeze date was dated 2014-11-05, with a file datestamp of 2014-10-31.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.182
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Aldo-keto reductase family 1 member C3
    Species: Homo sapiens [TaxId:9606]
    Gene: AKR1C3, DDH1, HSD17B5, KIAA0119, PGFS
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3r58a_
  • Heterogens: NAP, NPS, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3r58A (A:)
mdskhqcvklndghfmpvlgfgtyappevprskalevtklaieagfrhidsahlynneeq
vglairskiadgsvkredifytsklwstfhrpelvrpalenslkkaqldyvdlylihspm
slkpgeelsptdengkvifdivdlcttweamekckdaglaksigvsnfnrrqlemilnkp
glkykpvcnqvechpyfnrsklldfckskdivlvaysalgsqrdkrwvdpnspvlledpv
lcalakkhkrtpalialryqlqrgvvvlaksyneqrirqnvqvfefqltaedmkaidgld
rnlhyfnsdsfashpnypysdeylehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3r58A (A:)
qcvklndghfmpvlgfgtyappevprskalevtklaieagfrhidsahlynneeqvglai
rskiadgsvkredifytsklwstfhrpelvrpalenslkkaqldyvdlylihspmslkpi
fdivdlcttweamekckdaglaksigvsnfnrrqlemilnkpglkykpvcnqvechpyfn
rsklldfckskdivlvaysalgsqrdkrwvdpnspvlledpvlcalakkhkrtpalialr
yqlqrgvvvlaksyneqrirqnvqvfefqltaedmkaidgldrnlhyfnsdsfashpnyp
ysde