PDB entry 3r21

View 3r21 on RCSB PDB site
Description: Design, synthesis, and biological evaluation of pyrazolopyridine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (Part I)
Class: transferase/transferase inhibitor
Keywords: Kinase domain, transferase-transferase inhibitor complex
Deposited on 2011-03-11, released 2011-08-10
The last revision prior to the SCOPe 2.06 freeze date was dated 2012-02-29, with a file datestamp of 2012-02-24.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: 0.26
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: serine/threonine-protein kinase 6
    Species: Homo sapiens [TaxId:9606]
    Gene: AIK, ARK1, AURA, AURKA, BTAK, STK15, STK6
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3r21a_
  • Heterogens: D36, MG

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3r21A (A:)
gplgsrqwaledfeigrplgkgkfgnvylarekqskfilalkvlfkaqlekagvehqlrr
eveiqshlrhpnilrlygyfhdatrvylileyaplgtvyrelqklskfdeqrtatyitel
analsychskrvihrdikpenlllgsagelkiadfgwsvhapssrrddlcgtldylppem
iegrmhdekvdlwslgvlcyeflvgkppfeantyqetykrisrveftfpdfvtegardli
srllkhnpsqrpmlrevlehpwitansskps

    Sequence, based on observed residues (ATOM records): (download) 
    >3r21A (A:)
qwaledfeigrplgkgkfgnvylarekqskfilalkvlfkaqlekagvehqlrreveiqs
hlrhpnilrlygyfhdatrvylileyaplgtvyrelqklskfdeqrtatyitelanalsy
chskrvihrdikpenlllgsagelkiadfgwsvlcgtldylppemiegrmhdekvdlwsl
gvlcyeflvgkppfeantyqetykrisrveftfpdfvtegardlisrllkhnpsqrpmlr
evlehpwitanssk