PDB entry 3qzr

View 3qzr on RCSB PDB site
Description: Human enterovirus 71 3C protease mutant E71A in complex with rupintrivir
Class: hydrolase/hydrolase inhibitor
Keywords: chymotrypsin-fold, beta-ribbon, hydrolysis, nucleus, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2011-03-07, released 2011-08-10
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-09-28, with a file datestamp of 2011-09-23.
Experiment type: XRAY
Resolution: 1.04 Å
R-factor: 0.151
AEROSPACI score: 0.87 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 3C protein
    Species: Human enterovirus 71 [TaxId:39054]
    Gene: polyprotein
    Database cross-references and differences (RAF-indexed):
    • Uniprot E7E815 (4-End)
      • engineered mutation (74)
    Domains in SCOPe 2.05: d3qzra_
  • Chain 'B':
    Compound: 3C protein
    Species: Human enterovirus 71 [TaxId:39054]
    Gene: polyprotein
    Database cross-references and differences (RAF-indexed):
    • Uniprot E7E815
      • engineered mutation (74)
    Domains in SCOPe 2.05: d3qzrb_
  • Heterogens: AG7, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3qzrA (A:)
gshmgpsldfalsllrrnvrqvqtdqghftmlgvrdrlavlprhsqpgktiwiehklvnv
ldavelvdeqgvnlaltlitldtnekfrditkfipenistasdatlvintehmpsmfvpv
gdvvqygflnlsgkpthrtmmynfptkagqcggvvtsvgkiigihiggngrqgfcaglkr
syfaseq

    Sequence, based on observed residues (ATOM records): (download) 
    >3qzrA (A:)
gpsldfalsllrrnvrqvqtdqghftmlgvrdrlavlprhsqpgktiwiehklvnvldav
elvdeqgvnlaltlitldtnekfrditkfipenistasdatlvintehmpsmfvpvgdvv
qygflnlsgkpthrtmmynfptkagqcggvvtsvgkiigihiggngrqgfcaglkrsyfa

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3qzrB (B:)
gshmgpsldfalsllrrnvrqvqtdqghftmlgvrdrlavlprhsqpgktiwiehklvnv
ldavelvdeqgvnlaltlitldtnekfrditkfipenistasdatlvintehmpsmfvpv
gdvvqygflnlsgkpthrtmmynfptkagqcggvvtsvgkiigihiggngrqgfcaglkr
syfaseq

    Sequence, based on observed residues (ATOM records): (download) 
    >3qzrB (B:)
dfalsllrrnvrqvqtdqghftmlgvrdrlavlprhsqpgktiwiehklvnvldavelvd
eqgvnlaltlitldtnekfrditkfipenistasdatlvintehmpsmfvpvgdvvqygf
lnlsgkpthrtmmynfptkagqcggvvtsvgkiigihiggngrqgfcaglkrsyfa