PDB entry 3qwq

View 3qwq on RCSB PDB site
Description: Crystal structure of the extracellular domain of the epidermal growth factor receptor in complex with an adnectin
Class: protein binding/signaling protein
Keywords: CELL SURFACE RECEPTOR, TYROSINE KINASE, GLYCOPROTEIN, ADNECTIN, ANTITUMOR, DRUG, ENGINEERED BINDING PROTEIN, ANTIBODY MIMIC, SIGNALING PROTEIN, PROTEIN BINDING-SIGNALING PROTEIN complex
Deposited on 2011-02-28, released 2012-02-01
The last revision prior to the SCOPe 2.06 freeze date was dated 2012-02-29, with a file datestamp of 2012-02-24.
Experiment type: XRAY
Resolution: 2.75 Å
R-factor: 0.204
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB1
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: adnectin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 3QWQ
    Domains in SCOPe 2.06: d3qwqb_
  • Heterogens: NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3qwqB (B:)
mgvsdvprdlevvaatptslliswdsgrgsyqyyritygetggnspvqeftvpgpvhtat
isglkpgvdytitvyavtdhkphadgphtyhespisinyrteidkpsqhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3qwqB (B:)
dvprdlevvaatptslliswdsgrgsyqyyritygetggnspvqeftvpgpvhtatisgl
kpgvdytitvyavtdhkphadgphtyhespisinyrteid