SCOPe 2.08: Structural Classification of Proteins

PDB entry 3qu8

View 3qu8 on RCSB PDB site
Description: Crystal structure of a human cytochrome P450 2B6 (Y226H/K262R) in complex with the inhibitor 4-(4-Nitrobenzyl)pyridine.
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: P450, CYTOCHROME P450 2B6, MONOOXYGENASE, MEMBRANE PROTEIN, CYP2B6, ENDOPLASMIC RETICULUM, HEME, IRON, MEMBRANE, METAL BINDING, MICROSOME, PHOSPHOPROTEIN, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Deposited on 2011-02-23, released 2011-09-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2012-12-05, with a file datestamp of 2012-11-30.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.22
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: Cytochrome P450 2B6
Species: Homo sapiens [TaxId:9606]
Gene: CYP2B6
Database cross-references and differences (RAF-indexed):
- Uniprot P20813 (Start-471)
  - engineered mutation (8-9)
  - engineered mutation (206)
  - engineered mutation (242)
  - expression tag (472)
Domains in SCOPe 2.08: d3qu8a1, d3qu8a2
Chain 'B':
Compound: Cytochrome P450 2B6
Species: Homo sapiens [TaxId:9606]
Gene: CYP2B6
Database cross-references and differences (RAF-indexed):
- Uniprot P20813 (Start-471)
  - engineered mutation (8-9)
  - engineered mutation (206)
  - engineered mutation (242)
  - expression tag (472)
Domains in SCOPe 2.08: d3qu8b1, d3qu8b2
Chain 'C':
Compound: Cytochrome P450 2B6
Species: Homo sapiens [TaxId:9606]
Gene: CYP2B6
Database cross-references and differences (RAF-indexed):
- Uniprot P20813 (Start-471)
  - engineered mutation (8-9)
  - engineered mutation (206)
  - engineered mutation (242)
  - expression tag (472)
Domains in SCOPe 2.08: d3qu8c1, d3qu8c2
Chain 'D':
Compound: Cytochrome P450 2B6
Species: Homo sapiens [TaxId:9606]
Gene: CYP2B6
Database cross-references and differences (RAF-indexed):
- Uniprot P20813 (Start-471)
  - engineered mutation (8-9)
  - engineered mutation (206)
  - engineered mutation (242)
Domains in SCOPe 2.08: d3qu8d_
Chain 'E':
Compound: Cytochrome P450 2B6
Species: Homo sapiens [TaxId:9606]
Gene: CYP2B6
Database cross-references and differences (RAF-indexed):
- Uniprot P20813 (Start-471)
  - engineered mutation (8-9)
  - engineered mutation (206)
  - engineered mutation (242)
  - expression tag (472)
Domains in SCOPe 2.08: d3qu8e1, d3qu8e2
Chain 'F':
Compound: Cytochrome P450 2B6
Species: Homo sapiens [TaxId:9606]
Gene: CYP2B6
Database cross-references and differences (RAF-indexed):
- Uniprot P20813
  - engineered mutation (8-9)
  - engineered mutation (206)
  - engineered mutation (242)
Domains in SCOPe 2.08: d3qu8f_
Heterogens: HEM, 3QU, CM5, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>3qu8A (A:)
makktsskgklppgprplpllgnllqmdrrgllksflrfrekygdvftvhlgprpvvmlc
gveairealvdkaeafsgrgkiamvdpffrgygvifangnrwkvlrrfsvttmrdfgmgk
rsveeriqeeaqclieelrkskgalmdptflfqsitaniicsivfgkrfhyqdqeflkml
nlfyqtfslissvfgqlfelfsgflkhfpgahrqvyknlqeinayighsvekhretldps
aprdlidtyllhmekeksnahsefshqnlnlntlslffagtettsttlrygfllmlkyph
vaervyreieqvigphrppelhdrakmpyteaviyeiqrfsdllpmgvphivtqhtsfrg
yiipkdtevflilstalhdphyfekpdafnpdhfldangalkkteafipfslgkriclge
giaraelflffttilqnfsmaspvapedidltpqecgvgkipptyqirflprhhhh