PDB entry 3qs5

View 3qs5 on RCSB PDB site
Description: Crystal structure of LeuT mutant I359Q bound to sodium and L-tryptophan
Class: transport protein
Keywords: NSS, neurotransmitter, transporter, LeuT-fold, sodium-coupled secondary transporter, sodium and amino acid binding, membrane, TRANSPORT PROTEIN
Deposited on 2011-02-19, released 2011-10-12
The last revision prior to the SCOPe 2.05 freeze date was dated 2012-02-29, with a file datestamp of 2012-02-24.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.203
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Na(+):neurotransmitter symporter (Snf family)
    Species: Aquifex aeolicus [TaxId:63363]
    Gene: aq_2077, LeuT, snf
    Database cross-references and differences (RAF-indexed):
    • Uniprot O67854 (Start-512)
      • engineered mutation (358)
      • expression tag (513-514)
    Domains in SCOPe 2.05: d3qs5a_
  • Heterogens: TRP, NA, BOG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3qs5A (A:)
mevkrehwatrlglilamagnavglgnflrfpvqaaengggafmipyiiafllvgiplmw
iewamgryggaqghgttpaifyllwrnrfakilgvfglwiplvvaiyyvyieswtlgfai
kflvglvpepppnatdpdsilrpfkeflysyigvpkgdepilkpslfayivflitmfinv
silirgiskgierfakiamptlfilavflvirvflletpngtaadglnflwtpdfeklkd
pgvwiaavgqifftlslgfgaiityasyvrkdqdivlsgltaatlnekaevilggsisip
aavaffgvanavaiakagafnlgfitlpaifsqtaggtflgflwffllffagltssiaqm
qpmiafledelklsrkhavlwtaaivffsahlvmflnksldemdfwagtigvvffgltel
iiffwifgadkaweeinrggiikvpriyyyvmryitpaflavllvvwareyipkimeeth
wtvwitrfyiiglflfltflvflaerrrnhesagtlvpr

    Sequence, based on observed residues (ATOM records): (download) 
    >3qs5A (A:)
rehwatrlglilamagnavglgnflrfpvqaaengggafmipyiiafllvgiplmwiewa
mgryggaqghgttpaifyllwrnrfakilgvfglwiplvvaiyyvyieswtlgfaikflv
glvpeppptdpdsilrpfkeflysyigvpkgdepilkpslfayivflitmfinvsilirg
iskgierfakiamptlfilavflvirvflletpngtaadglnflwtpdfeklkdpgvwia
avgqifftlslgfgaiityasyvrkdqdivlsgltaatlnekaevilggsisipaavaff
gvanavaiakagafnlgfitlpaifsqtaggtflgflwffllffagltssiaqmqpmiaf
ledelklsrkhavlwtaaivffsahlvmflnksldemdfwagtigvvffglteliiffwi
fgadkaweeinrggiikvpriyyyvmryitpaflavllvvwareyipkimeethwtvwit
rfyiiglflfltflvflaerrrnhesagt