PDB entry 3qrd

View 3qrd on RCSB PDB site
Description: Crystal structure of L68V mutant of human cystatin C
Class: hydrolase inhibitor
Keywords: cysteine protease inhibitor, 3D domain swapping, protein, Hereditary Cystatin C Amyloid Angiopathy, Protease inhibitor, HYDROLASE INHIBITOR
Deposited on 2011-02-17, released 2012-02-29
The last revision prior to the SCOPe 2.03 freeze date was dated 2012-02-29, with a file datestamp of 2012-02-24.
Experiment type: XRAY
Resolution: 2.19 Å
R-factor: 0.218
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cystatin-C
    Species: Homo sapiens [TaxId:9606]
    Gene: CST3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01034 (Start-119)
      • engineered mutation (67)
    Domains in SCOPe 2.03: d3qrda_
  • Chain 'B':
    Compound: Cystatin-C
    Species: Homo sapiens [TaxId:9606]
    Gene: CST3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01034 (Start-119)
      • engineered mutation (67)
    Domains in SCOPe 2.03: d3qrdb_
  • Chain 'C':
    Compound: Cystatin-C
    Species: Homo sapiens [TaxId:9606]
    Gene: CST3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01034 (Start-119)
      • engineered mutation (67)
    Domains in SCOPe 2.03: d3qrdc_
  • Chain 'D':
    Compound: Cystatin-C
    Species: Homo sapiens [TaxId:9606]
    Gene: CST3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01034 (Start-119)
      • engineered mutation (67)
    Domains in SCOPe 2.03: d3qrdd_
  • Heterogens: PEG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3qrdA (A:)
sspgkpprlvggpmdasveeegvrraldfavgeynkasndmyhsralqvvrarkqivagv
nyfldvevgrttctktqpnldncpfhdqphlkrkafcsfqiyavpwqgtmtlskstcqda

    Sequence, based on observed residues (ATOM records): (download) 
    >3qrdA (A:)
vggpmdasveeegvrraldfavgeynkasndmyhsralqvvrarkqivagvnyfldvevg
rttctktqpnldncpfhdqphlkrkafcsfqiyavpwqgtmtlskstcqda

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3qrdB (B:)
sspgkpprlvggpmdasveeegvrraldfavgeynkasndmyhsralqvvrarkqivagv
nyfldvevgrttctktqpnldncpfhdqphlkrkafcsfqiyavpwqgtmtlskstcqda

    Sequence, based on observed residues (ATOM records): (download) 
    >3qrdB (B:)
gpmdasveeegvrraldfavgeynkasndmyhsralqvvrarkqivagvnyfldvevgrt
tctktqpnldncpfhkrkafcsfqiyavpwqgtmtlskstcqda

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3qrdC (C:)
sspgkpprlvggpmdasveeegvrraldfavgeynkasndmyhsralqvvrarkqivagv
nyfldvevgrttctktqpnldncpfhdqphlkrkafcsfqiyavpwqgtmtlskstcqda

    Sequence, based on observed residues (ATOM records): (download) 
    >3qrdC (C:)
pmdasveeegvrraldfavgeynkasndmyhsralqvvrarkqivagvnyfldvevgrtt
ctktqpnldncpfhdqphlkrkafcsfqiyavpwqgtmtlskstcqda

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3qrdD (D:)
sspgkpprlvggpmdasveeegvrraldfavgeynkasndmyhsralqvvrarkqivagv
nyfldvevgrttctktqpnldncpfhdqphlkrkafcsfqiyavpwqgtmtlskstcqda

    Sequence, based on observed residues (ATOM records): (download) 
    >3qrdD (D:)
vggpmdasveeegvrraldfavgeynkasndmyhsralqvvrarkqivagvnyfldvevg
rttctktqpnldncpfhdqphlkrkafcsfqiyavpwqgtmtlskstcqda