PDB entry 3qnf

View 3qnf on RCSB PDB site
Description: Crystal structure of the open state of human endoplasmic reticulum aminopeptidase 1 ERAP1
Class: hydrolase
Keywords: Structural Genomics Consortium, SGC, glycoprotein, metal-binding, metalloprotease, protease, adaptive immunity, HYDROLASE
Deposited on 2011-02-08, released 2011-02-23
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-05-25, with a file datestamp of 2011-05-20.
Experiment type: XRAY
Resolution: 3 Å
R-factor: 0.231
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: endoplasmic reticulum aminopeptidase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: ERAP1, APPILS, ARTS1, KIAA0525, UNQ584/PRO1154
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3qnfa1, d3qnfa2, d3qnfa3
  • Chain 'B':
    Compound: endoplasmic reticulum aminopeptidase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: ERAP1, APPILS, ARTS1, KIAA0525, UNQ584/PRO1154
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3qnfb1, d3qnfb2, d3qnfb3, d3qnfb4
  • Chain 'C':
    Compound: endoplasmic reticulum aminopeptidase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: ERAP1, APPILS, ARTS1, KIAA0525, UNQ584/PRO1154
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3qnfc1, d3qnfc2, d3qnfc3, d3qnfc4
  • Heterogens: ZN, NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3qnfA (A:)
lrrrytmvflplkwslatmsfllssllalltvstpswcqsteaspkrsdgtpfpwnkirl
peyvipvhydllihanlttltfwgttkveitasqptstiilhshhlqisratlrkgager
lseeplqvlehprqeqiallapepllvglpytvvihyagnlsetfhgfykstyrtkegel
rilastqfeptaarmafpcfdepafkasfsikirreprhlaisnmplvksvtvaeglied
hfdvtvkmstylvafiisdfesvskitksgvkvsvyavpdkinqadyaldaavtllefye
dyfsipyplpkqdlaaipdfqsgamenwglttyresallfdaekssassklgitmtvahe
lahqwfgnlvtmewwndlwlnegfakfmefvsvsvthpelkvgdyffgkcfdamevdaln
sshpvstpvenpaqiremfddvsydkgacilnmlreylsadafksgivqylqkhsykntk
nedlwdsmasicptdgvkgmdgfcsrsqhssssshwhqegvdvktmmntwtlqkgfplit
itvrgrnvhmkqehymkgsdgapdtgylwhvpltfitsksdmvhrfllktktdvlilpee
vewikfnvgmngyyivhyeddgwdsltgllkgthtavssndraslinnafqlvsigklsi
ekaldlslylkheteimpvfqglnelipmyklmekrdmnevetqfkaflirllrdlidkq
twtdegsvsermlrsqllllacvhnyqpcvqraegyfrkwkesngnlslpvdvtlavfav
gaqstegwdflyskyqfslssteksqiefalcrtqnkeklqwlldesfkgdkiktqefpq
iltligrnpvgyplawqflrknwnklvqkfelgsssiahmvmgttnqfstrtrleevkgf
fsslkengsqlrcvqqtietieenigwmdknfdkirvwlqseklermaenlyfq

    Sequence, based on observed residues (ATOM records): (download) 
    >3qnfA (A:)
pfpwnkirlpeyvipvhydllihanlttltfwgttkveitasqptstiilhshhlqisra
tlrkglseeplqvlehprqeqiallapepllvglpytvvihyagnlsetfhgfykstyrt
kegelrilastqfeptaarmafpcfdepafkasfsikirreprhlaisnmplvksvtvae
gliedhfdvtvkmstylvafiisdfesvskitksgvkvsvyavpdkinqadyaldaavtl
lefyedyfsipyplpkqdlaaipdfqsgamenwglttyresallfdaekssassklgitm
tvahelahqwfgnlvtmewwndlwlnegfakfmefvsvsvthpelkvgdyffgkcfdame
vdalnsshpvstpvenddvsydkgacilnmlreylsadafksgivqylqkhsykntkned
lwdsmasivdvktmmntwtlqkgfplititvrgrnvhmkqehymktgylwhvpltfitsk
sdmvhrfllktktdvlilpeevewikfnvgmngyyivhyeddgwdsltgllkgthtavss
ndraslinnafqlvsigklsiekaldlslylkheteimpvfqglnelipmyklmekrdmn
evetqfkaflirllrdlidkqtwtdegsvsermlrsqllllacvhnyqpcvqraegyfrk
wkesqiefalcrtqnieenigwmdknfdkirvwlqs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3qnfB (B:)
lrrrytmvflplkwslatmsfllssllalltvstpswcqsteaspkrsdgtpfpwnkirl
peyvipvhydllihanlttltfwgttkveitasqptstiilhshhlqisratlrkgager
lseeplqvlehprqeqiallapepllvglpytvvihyagnlsetfhgfykstyrtkegel
rilastqfeptaarmafpcfdepafkasfsikirreprhlaisnmplvksvtvaeglied
hfdvtvkmstylvafiisdfesvskitksgvkvsvyavpdkinqadyaldaavtllefye
dyfsipyplpkqdlaaipdfqsgamenwglttyresallfdaekssassklgitmtvahe
lahqwfgnlvtmewwndlwlnegfakfmefvsvsvthpelkvgdyffgkcfdamevdaln
sshpvstpvenpaqiremfddvsydkgacilnmlreylsadafksgivqylqkhsykntk
nedlwdsmasicptdgvkgmdgfcsrsqhssssshwhqegvdvktmmntwtlqkgfplit
itvrgrnvhmkqehymkgsdgapdtgylwhvpltfitsksdmvhrfllktktdvlilpee
vewikfnvgmngyyivhyeddgwdsltgllkgthtavssndraslinnafqlvsigklsi
ekaldlslylkheteimpvfqglnelipmyklmekrdmnevetqfkaflirllrdlidkq
twtdegsvsermlrsqllllacvhnyqpcvqraegyfrkwkesngnlslpvdvtlavfav
gaqstegwdflyskyqfslssteksqiefalcrtqnkeklqwlldesfkgdkiktqefpq
iltligrnpvgyplawqflrknwnklvqkfelgsssiahmvmgttnqfstrtrleevkgf
fsslkengsqlrcvqqtietieenigwmdknfdkirvwlqseklermaenlyfq

    Sequence, based on observed residues (ATOM records): (download) 
    >3qnfB (B:)
pfpwnkirlpeyvipvhydllihanlttltfwgttkveitasqptstiilhshhlqisra
tlrklseeplqvlehprqeqiallapepllvglpytvvihyagnlsetfhgfykstyrtk
egelrilastqfeptaarmafpcfdepafkasfsikirreprhlaisnmplvksvtvaeg
liedhfdvtvkmstylvafiisdfesvskitksgvkvsvyavpdkinqadyaldaavtll
efyedyfsipyplpkqdlaaipdfqsgamenwglttyresallfdaekssassklgitmt
vahelahqwfgnlvtmewwndlwlnegfakfmefvsvsvthpelkvgdyffgkcfdamev
dalnsshpvstpvenpmfddvsydkgacilnmlreylsadafksgivqylqkhsykntkn
edlwdsmasivdvktmmntwtlqkgfplititvrgrnvhmkqehymtgylwhvpltfits
ksdmvhrfllktktdvlilpeevewikfnvgmngyyivhyeddgwdsltgllkgthtavs
sndraslinnafqlvsigklsiekaldlslylkheteimpvfqglnelipmyklmekrdm
nevetqfkaflirllrdlidkqtwtdegsvsermlrsqllllacvhnyqpcvqraegyfr
kwkesngnlslpvdvtlavfavgaqstegwdflyskyqfslssteksqiefalcrtqnke
klqwlldetqefpqiltligrnpvgyplawqflrkahmvmgttnqfstrtrleevqqtie
tieenigwmdknfdkirvwlqs

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3qnfC (C:)
lrrrytmvflplkwslatmsfllssllalltvstpswcqsteaspkrsdgtpfpwnkirl
peyvipvhydllihanlttltfwgttkveitasqptstiilhshhlqisratlrkgager
lseeplqvlehprqeqiallapepllvglpytvvihyagnlsetfhgfykstyrtkegel
rilastqfeptaarmafpcfdepafkasfsikirreprhlaisnmplvksvtvaeglied
hfdvtvkmstylvafiisdfesvskitksgvkvsvyavpdkinqadyaldaavtllefye
dyfsipyplpkqdlaaipdfqsgamenwglttyresallfdaekssassklgitmtvahe
lahqwfgnlvtmewwndlwlnegfakfmefvsvsvthpelkvgdyffgkcfdamevdaln
sshpvstpvenpaqiremfddvsydkgacilnmlreylsadafksgivqylqkhsykntk
nedlwdsmasicptdgvkgmdgfcsrsqhssssshwhqegvdvktmmntwtlqkgfplit
itvrgrnvhmkqehymkgsdgapdtgylwhvpltfitsksdmvhrfllktktdvlilpee
vewikfnvgmngyyivhyeddgwdsltgllkgthtavssndraslinnafqlvsigklsi
ekaldlslylkheteimpvfqglnelipmyklmekrdmnevetqfkaflirllrdlidkq
twtdegsvsermlrsqllllacvhnyqpcvqraegyfrkwkesngnlslpvdvtlavfav
gaqstegwdflyskyqfslssteksqiefalcrtqnkeklqwlldesfkgdkiktqefpq
iltligrnpvgyplawqflrknwnklvqkfelgsssiahmvmgttnqfstrtrleevkgf
fsslkengsqlrcvqqtietieenigwmdknfdkirvwlqseklermaenlyfq

    Sequence, based on observed residues (ATOM records): (download) 
    >3qnfC (C:)
fpwnkirlpeyvipvhydllihanlttltfwgttkveitasqptstiilhshhlqisrat
lrkgalseeplqvlehprqeqiallapepllvglpytvvihyagnlsetfhgfykstyrt
kegelrilastqfeptaarmafpcfdepafkasfsikirreprhlaisnmplvksvtvae
gliedhfdvtvkmstylvafiisdfesvskitksgvkvsvyavpdkinqadyaldaavtl
lefyedyfsipyplpkqdlaaipdfqsgamenwglttyresallfdaekssassklgitm
tvahelahqwfgnlvtmewwndlwlnegfakfmefvsvsvthpelkvgdyffgkcfdame
vdalnsshpvstpvenpdvsydkgacilnmlreylsadafksgivqylqkhsykntkned
lwdsmasivdvktmmntwtlqkgfplititvrgrnvhmkqehymktgylwhvpltfitsk
sdmvhrfllktktdvlilpeevewikfnvgmngyyivhyeddgwdsltgllkgthtavss
ndraslinnafqlvsigklsiekaldlslylkheteimpvfqglnelipmyklmekrdmn
evetqfkaflirllrdlidkqtwtdegsvsermlrsqllllacvhnyqpcvqraegyfrk
wkesngnlslpvdvtlavfavgaqstegwdflyskyqfslssteksqiefalcrtqnkek
lqwllqiltligrnpvgyplawqflrksiahmvmgttnqfstrtrleevkgqqtietiee
nigwmdknfdkirvwlqsek