PDB entry 3qlf

View 3qlf on RCSB PDB site
Description: Crystal structure of the L317I mutant of the C-src tyrosine kinase domain complexed with pyrazolopyrimidine 5
Class: transferase
Keywords: c-src l317i mutant, tyrosine kinase, transferase, pyrazolopyrimidine 5
Deposited on 2011-02-02, released 2012-02-08
The last revision prior to the SCOPe 2.03 freeze date was dated 2012-02-08, with a file datestamp of 2012-02-03.
Experiment type: XRAY
Resolution: 2.75 Å
R-factor: 0.194
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Proto-oncogene tyrosine-protein kinase Src
    Species: Gallus gallus [TaxId:9031]
    Gene: SRC
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00523 (Start-285)
      • engineered mutation (69)
    Domains in SCOPe 2.03: d3qlfa_
  • Chain 'B':
    Compound: Proto-oncogene tyrosine-protein kinase Src
    Species: Gallus gallus [TaxId:9031]
    Gene: SRC
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00523 (Start-285)
      • engineered mutation (69)
    Domains in SCOPe 2.03: d3qlfb_
  • Heterogens: PD5, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3qlfA (A:)
ghmqtqglakdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaf
lqeaqvmkkirheklvqlyavvseepiyivteymskgslldflkgemgkylrlpqlvdma
aqiasgmayvermnyvhrdlraanilvgenlvckvadfglarliedneytarqgakfpik
wtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppec
peslhdlmcqcwrkdpeerptfeylqafledyftstepqyqpgenl

    Sequence, based on observed residues (ATOM records): (download) 
    >3qlfA (A:)
daweipreslrlevklgqgcfgevwmgtwngttrvaiktlklqeaqvmkkirheklvqly
avvseepiyivteymskgslldflkgemgkylrlpqlvdmaaqiasgmayvermnyvhrd
lraanilvgenlvckvadffpikwtapeaalygrftiksdvwsfgilltelttkgrvpyp
gmvnrevldqvergyrmpcppecpeslhdlmcqcwrkdpeerptfeylqafledyftste
pqyqpgenl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3qlfB (B:)
ghmqtqglakdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaf
lqeaqvmkkirheklvqlyavvseepiyivteymskgslldflkgemgkylrlpqlvdma
aqiasgmayvermnyvhrdlraanilvgenlvckvadfglarliedneytarqgakfpik
wtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppec
peslhdlmcqcwrkdpeerptfeylqafledyftstepqyqpgenl

    Sequence, based on observed residues (ATOM records): (download) 
    >3qlfB (B:)
daweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpmspeaflqeaqvmkkirh
eklvqlyavvseepiyivteymskgslldflkgemgkylrlpqlvdmaaqiasgmayver
mnyvhrdlraanilvgenlvckvadfarfpikwtapeaalygrftiksdvwsfgilltel
ttkgrvpypgmvnrevldqvergyrmpcppecpeslhdlmcqcwrkdpeerptfeylqaf
ledyftstepqyqpgenl