PDB entry 3qeo

View 3qeo on RCSB PDB site
Description: S74E-R104M-D133A dCK variant in complex with L-deoxythymidine and UDP
Class: transferase
Keywords: alpha/beta, phosphoryl transfer, TRANSFERASE
Deposited on 2011-01-20, released 2011-03-16
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-04-20, with a file datestamp of 2011-04-15.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.2
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Deoxycytidine kinase
    Species: Homo sapiens [TaxId:9606]
    Gene: DCK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27707 (Start-278)
      • engineered mutation (63)
      • engineered mutation (77)
      • engineered mutation (92)
      • engineered mutation (122)
      • engineered mutation (151)
      • expression tag (164)
      • engineered mutation (164)
    Domains in SCOPe 2.05: d3qeoa_
  • Chain 'B':
    Compound: Deoxycytidine kinase
    Species: Homo sapiens [TaxId:9606]
    Gene: DCK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27707 (Start-278)
      • engineered mutation (63)
      • engineered mutation (77)
      • engineered mutation (92)
      • engineered mutation (122)
      • engineered mutation (151)
      • expression tag (164)
      • engineered mutation (164)
    Domains in SCOPe 2.05: d3qeob_
  • Heterogens: UDP, LLT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3qeoA (A:)
mgsshhhhhhsglvprgshmatppkrsspsfsassegtrikkisiegniaagkstfvnil
kqlsedwevvpepvarwsnvqstqdefeeltmeqknggnvlqmmyekperwsftfqtyac
lsmiraqlaslngklkdaekpvlffersvysaryifasnlyesesmnetewtiyqdwhdw
mnnqfgqsleldgiiylqatpetclhriylrgrneeqgipleyleklhykheswllhrtl
ktnfdylqevpiltldvnedfkdkyeslvekvkeflstl

    Sequence, based on observed residues (ATOM records): (download) 
    >3qeoA (A:)
trikkisiegniaagkstfvnilkqlsedwevvpepvarwsnveltmeqknggnvlqmmy
ekperwsftfqtyaclsmiraqlaslngklkdaekpvlffersvysaryifasnlyeses
mnetewtiyqdwhdwmnnqfgqsleldgiiylqatpetclhriylrgrneeqgipleyle
klhykheswllhrtlktnfdylqevpiltldvnedfkdkyeslvekvkeflstl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3qeoB (B:)
mgsshhhhhhsglvprgshmatppkrsspsfsassegtrikkisiegniaagkstfvnil
kqlsedwevvpepvarwsnvqstqdefeeltmeqknggnvlqmmyekperwsftfqtyac
lsmiraqlaslngklkdaekpvlffersvysaryifasnlyesesmnetewtiyqdwhdw
mnnqfgqsleldgiiylqatpetclhriylrgrneeqgipleyleklhykheswllhrtl
ktnfdylqevpiltldvnedfkdkyeslvekvkeflstl

    Sequence, based on observed residues (ATOM records): (download) 
    >3qeoB (B:)
trikkisiegniaagkstfvnilkqlsedwevvpepvarwsnvqltmeqknggnvlqmmy
ekperwsftfqtyaclsmiraqlaslngklkdaekpvlffersvysaryifasnlyeses
mnetewtiyqdwhdwmnnqfgqsleldgiiylqatpetclhriylrgrneeqgipleyle
klhykheswllhrtlktnfdylqevpiltldvnedfkdkyeslvekvkeflstl