PDB entry 3qdm

View 3qdm on RCSB PDB site
Description: The complex between TCR DMF4 and human Class I MHC HLA-A2 with the bound MART-1(26-35)(A27L) decameric peptide
Class: immune system
Keywords: MART-1 peptide, nonapeptide, MHC class I, HLA-A2, TCR DMF5, TCR DMF4, cross-reactivity, cancer, melanoma, IMMUNE SYSTEM
Deposited on 2011-01-18, released 2011-07-06
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-09-07, with a file datestamp of 2011-09-02.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.215
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: HLA class I histocompatibility antigen, A-2 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-A, HLAA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3qdma1, d3qdma2
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • initiating methionine (0)
    Domains in SCOPe 2.06: d3qdmb1, d3qdmb2
  • Chain 'C':
    Compound: MART-1(27-35) peptide
    Database cross-references and differences (RAF-indexed):
    • PDB 3QDM (0-9)
  • Chain 'D':
    Compound: DMF4 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 3QDM (0-194)
    Domains in SCOPe 2.06: d3qdmd1, d3qdmd2
  • Chain 'E':
    Compound: DMF4 beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 3QDM (0-241)
    Domains in SCOPe 2.06: d3qdme1, d3qdme2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3qdmA (A:)
    gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
    dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
    kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
    rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
    fqkwaavvvpsgqeqrytchvqheglpkpltlrwe
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3qdmB (B:)
    miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
    wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3qdmD (D:)
    qlnqspqsmfiqegedvsmnctsssifntwlwykqdpgegpvllialykageltsngrlt
    aqfgitrkdsflnisasipsdvgiyfcaggtgnqfyfgtgtsltvipniqnpdpavyqlr
    dskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnksdfac
    anafnnsiipedtff
    

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3qdmE (E:)
    agitqsprhkvtetgtpvtlrchqtenhrymywyrqdpghglrlihysygvkdtdkgevs
    dgysvsrsktedflltlesatssqtsvyfcaisevgvgqpqhfgdgtrlsiledlnkvfp
    pevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeqpa
    lndsryalssrlrvsatfwqdprnhfrcqvqfyglsendewtqdrakpvtqivsaeawgr
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