PDB entry 3qc4

View 3qc4 on RCSB PDB site
Description: PDK1 in complex with DFG-OUT inhibitor xxx
Class: transferase/transferase inhibitor
Keywords: serine/threonine kinase, phosphorylation, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2011-01-15, released 2011-04-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-05-18, with a file datestamp of 2011-05-13.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.174
AEROSPACI score: 0.51 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 3-phosphoinositide-dependent protein kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PDPK1, PDK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O15530 (Start-313)
      • engineered mutation (257-258)
    Domains in SCOPe 2.08: d3qc4a_
  • Chain 'B':
    Compound: 3-phosphoinositide-dependent protein kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PDPK1, PDK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O15530 (5-313)
      • expression tag (0-4)
      • engineered mutation (257-258)
    Domains in SCOPe 2.08: d3qc4b1, d3qc4b2
  • Heterogens: MP7, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3qc4A (A:)
gplgsmdgtaaeprpgagslqhaqpppqprkkrpedfkfgkilgegsfstvvlarelats
reyaikilekrhiikenkvpyvtrerdvmsrldhpffvklyftfqddeklyfglsyakng
ellkyirkigsfdetctrfytaeivsaleylhgkgiihrdlkpenillnedmhiqitdfg
takvlspeskqaransfvgtaqyvspellteksackssdlwalgciiyqlvaglppfrag
neylifqkiikleydfpaaffpkardlvekllvldatkrlgceemegygplkahpffesv
twenlhqqtppklt

    Sequence, based on observed residues (ATOM records): (download) 
    >3qc4A (A:)
kkrpedfkfgkilgegsfstvvlarelatsreyaikilekrhiikenkvpyvtrerdvms
rldhpffvklyftfqddeklyfglsyakngellkyirkigsfdetctrfytaeivsaley
lhgkgiihrdlkpenillnedmhiqitdfgtakvlsansfvgtaqyvspellteksacks
sdlwalgciiyqlvaglppfragneylifqkiikleydfpaaffpkardlvekllvldat
krlgceemegygplkahpffesvtwenlhqqtppklt

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3qc4B (B:)
gplgsmdgtaaeprpgagslqhaqpppqprkkrpedfkfgkilgegsfstvvlarelats
reyaikilekrhiikenkvpyvtrerdvmsrldhpffvklyftfqddeklyfglsyakng
ellkyirkigsfdetctrfytaeivsaleylhgkgiihrdlkpenillnedmhiqitdfg
takvlspeskqaransfvgtaqyvspellteksackssdlwalgciiyqlvaglppfrag
neylifqkiikleydfpaaffpkardlvekllvldatkrlgceemegygplkahpffesv
twenlhqqtppklt

    Sequence, based on observed residues (ATOM records): (download) 
    >3qc4B (B:)
gplgsmdgtakkrpedfkfgkilgegsfstvvlarelatsreyaikilekrhivtrerdv
msrldhpffvklyftfqddeklyfglsyakngellkyirkigsfdetctrfytaeivsal
eylhgkgiihrdlkpenillnedmhiqitdfgtakvlsansfvgtaqyvspellteksac
kssdlwalgciiyqlvaglppfragneylifqkiikleydfpaaffpkardlvekllvld
atkrlgceemegygplkahpffesvtwenlhqqtppklt