PDB entry 3qbj

View 3qbj on RCSB PDB site
Description: Crystal structure of dipeptidyl peptidase IV in complex with inhibitor
Class: hydrolase/hydrolase inhibitor
Keywords: Diabetes Mellitus, Dipeptidyl-Peptidase IV Inhibitor, Hypoglycemic Agent, Pyrrolidines, Sprague-Dawley, Structure-Activity Relationship, hydrolase, glycosylation, hydrolase-hydrolase inhibitor complex
Deposited on 2011-01-13, released 2012-01-25
The last revision prior to the SCOPe 2.06 freeze date was dated 2012-01-25, with a file datestamp of 2012-01-20.
Experiment type: XRAY
Resolution: 2.21 Å
R-factor: 0.203
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dipeptidyl peptidase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: DPP4, ADCP2, CD26
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27487 (Start-735)
      • engineered mutation (119)
      • engineered mutation (489)
    Domains in SCOPe 2.06: d3qbja1, d3qbja2
  • Chain 'B':
    Compound: dipeptidyl peptidase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: DPP4, ADCP2, CD26
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27487 (Start-735)
      • engineered mutation (119)
      • engineered mutation (489)
    Domains in SCOPe 2.06: d3qbjb1, d3qbjb2
  • Heterogens: NAG, NXZ, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3qbjA (A:)
gtddatadsrktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnssvfl
enstfdefghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripa
ntqwvtwspvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsa
ysalwwspngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffv
vntdslssvtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdy
dessgrwnclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqid
kkdctfitkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclsceln
percqyysvsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmp
skkldfiilaetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylast
eniivasfdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgws
yggyvtsmvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvms
raenfkqveyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqh
iythmshfikqcfslplvprgshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3qbjA (A:)
srktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnssvflenstfdef
ghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripantqwvtws
pvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalwwsp
ngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntdslss
vtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessgrwn
clvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkdctfit
kgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercqyys
vsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkldfii
laetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniivasf
dgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyvtsm
vlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenfkqv
eyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythmshf
ikqcfslp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3qbjB (B:)
gtddatadsrktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnssvfl
enstfdefghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripa
ntqwvtwspvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsa
ysalwwspngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffv
vntdslssvtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdy
dessgrwnclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqid
kkdctfitkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclsceln
percqyysvsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmp
skkldfiilaetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylast
eniivasfdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgws
yggyvtsmvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvms
raenfkqveyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqh
iythmshfikqcfslplvprgshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3qbjB (B:)
srktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnssvflenstfdef
ghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripantqwvtws
pvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalwwsp
ngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntdslss
vtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessgrwn
clvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkdctfit
kgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercqyys
vsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkldfii
laetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniivasf
dgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyvtsm
vlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenfkqv
eyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythmshf
ikqcfslp