PDB entry 3qb4

View 3qb4 on RCSB PDB site
Description: Crystal structure of a TGF-beta ligand-receptor complex
Class: cytokine/transferase receptor
Keywords: CYSTINE-KNOT, Ligand-receptor complex, Protein, Membrane/Extracellular, CYTOKINE-TRANSFERASE RECEPTOR complex
Deposited on 2011-01-12, released 2012-03-14
The last revision prior to the SCOPe 2.05 freeze date was dated 2012-03-14, with a file datestamp of 2012-03-09.
Experiment type: XRAY
Resolution: 2.28 Å
R-factor: 0.2
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Growth/differentiation factor 5
    Species: Homo sapiens [TaxId:9606]
    Gene: CDMP1, GDF5
    Database cross-references and differences (RAF-indexed):
    • Uniprot P43026 (Start-116)
      • engineered mutation (53)
    Domains in SCOPe 2.05: d3qb4a_
  • Chain 'B':
    Compound: Bone morphogenetic protein receptor type-1A
    Species: Homo sapiens [TaxId:9606]
    Gene: ACVRLK3, ALK3, BMPR1A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3qb4b_
  • Chain 'C':
    Compound: Growth/differentiation factor 5
    Species: Homo sapiens [TaxId:9606]
    Gene: CDMP1, GDF5
    Database cross-references and differences (RAF-indexed):
    • Uniprot P43026 (Start-116)
      • engineered mutation (53)
    Domains in SCOPe 2.05: d3qb4c_
  • Chain 'D':
    Compound: Bone morphogenetic protein receptor type-1A
    Species: Homo sapiens [TaxId:9606]
    Gene: ACVRLK3, ALK3, BMPR1A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3qb4d_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3qb4A (A:)
mkrqgkrpsknlkarcsrkalhvnfkdmgwddwiiapleyeafhceglcefplashlept
nhaviqtlmnsmdpestpptccvptrlspisilfidsannvvykqyedmvvescgcr

    Sequence, based on observed residues (ATOM records): (download) 
    >3qb4A (A:)
karcsrkalhvnfkdmgwddwiiapleyeafhceglcefplashleptnhaviqtlmnsm
dpestpptccvptrlspisilfidsannvvykqyedmvvescgcr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3qb4B (B:)
gsgamaqnldsmlhgtgmksdsdqkksengvtlapedtlpflkcycsghcpddainntci
tnghcfaiieeddqgettlasgcmkyegsdfqckdspkaqlrrtieccrtnlcnqylqpt
lppvvigpffdgsir

    Sequence, based on observed residues (ATOM records): (download) 
    >3qb4B (B:)
dtlpflkcycsghcpddainntcitnghcfaiieeddqgettlasgcmkyegsdfqckds
pkaqlrrtieccrtnlcnqylqptlppv

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3qb4C (C:)
mkrqgkrpsknlkarcsrkalhvnfkdmgwddwiiapleyeafhceglcefplashlept
nhaviqtlmnsmdpestpptccvptrlspisilfidsannvvykqyedmvvescgcr

    Sequence, based on observed residues (ATOM records): (download) 
    >3qb4C (C:)
lkarcsrkalhvnfkdmgwddwiiapleyeafhceglcefplashleptnhaviqtlmns
mdpestpptccvptrlspisilfidsannvvykqyedmvvescgcr

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3qb4D (D:)
gsgamaqnldsmlhgtgmksdsdqkksengvtlapedtlpflkcycsghcpddainntci
tnghcfaiieeddqgettlasgcmkyegsdfqckdspkaqlrrtieccrtnlcnqylqpt
lppvvigpffdgsir

    Sequence, based on observed residues (ATOM records): (download) 
    >3qb4D (D:)
dtlpflkcycsghcpddainntcitnghcfaiieeddqgettlasgcmkyegsdfqckds
pkaqlrrtieccrtnlcnqylqptlppvv