PDB entry 3q96

View 3q96 on RCSB PDB site
Description: B-Raf kinase domain in complex with a tetrahydronaphthalene inhibitor
Class: transferase/transferase inhibitor
Keywords: Design, Optimization, Potent, Orally Bioavailable, Tetrahydronaphthalene, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2011-01-07, released 2011-03-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-08, with a file datestamp of 2017-11-03.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: N/A
AEROSPACI score: 0.12 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein kinase B-raf
    Species: Homo sapiens [TaxId:9606]
    Gene: BRAF, BRAF1, RAFB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3q96a_
  • Chain 'B':
    Compound: Serine/threonine-protein kinase B-raf
    Species: Homo sapiens [TaxId:9606]
    Gene: BRAF, BRAF1, RAFB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3q96b_
  • Heterogens: 0NF

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3q96A (A:)
ssddweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvl
rktrhvnillfmgystkpqlaivtqwcegsslyhhlhiietkfemiklidiarqtaqgmd
ylhaksiihrdlksnniflhedltvkigdfglatvksrwsgshqfeqlsgsilwmapevi
rmqdknpysfqsdvyafgivlyelmtgqlpysninnrdqiifmvgrgylspdlskvrsnc
pkamkrlmaeclkkkrderplfpqilasiellarslpkihrs

    Sequence, based on observed residues (ATOM records): (download) 
    >3q96A (A:)
dweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrkt
rhvnillfmgystkpqlaivtqwcegsslyhhlhiietkfemiklidiarqtaqgmdylh
aksiihrdlksnniflhedltvkigdfglsilwmapevirmnpysfqsdvyafgivlyel
mtgqlpysninnrdqiifmvgrgylspdlskvrsncpkamkrlmaeclkkkrderplfpq
ilasiellarslp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3q96B (B:)
ssddweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvl
rktrhvnillfmgystkpqlaivtqwcegsslyhhlhiietkfemiklidiarqtaqgmd
ylhaksiihrdlksnniflhedltvkigdfglatvksrwsgshqfeqlsgsilwmapevi
rmqdknpysfqsdvyafgivlyelmtgqlpysninnrdqiifmvgrgylspdlskvrsnc
pkamkrlmaeclkkkrderplfpqilasiellarslpkihrs

    Sequence, based on observed residues (ATOM records): (download) 
    >3q96B (B:)
dweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrkt
rhvnillfmgystkpqlaivtqwcegsslyhhlhiietkfemiklidiarqtaqgmdylh
aksiihrdlksnniflhedltvkigdfglatvksrwgsilwmapevirmqdknpysfqsd
vyafgivlyelmtgqlpysninnrdqiifmvgrgylspdlskvrsncpkamkrlmaeclk
kkrderplfpqilasiellars