PDB entry 3q4t

View 3q4t on RCSB PDB site
Description: Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with dorsomorphin
Class: transferase
Keywords: Structural Genomics Consortium, SGC, Protein kinase, TRANSFERASE
Deposited on 2010-12-24, released 2011-02-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2015-02-25, with a file datestamp of 2015-02-20.
Experiment type: XRAY
Resolution: 1.96 Å
R-factor: 0.171
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Activin receptor type-2A
    Species: Homo sapiens [TaxId:9606]
    Gene: ACVR2, ACVR2A
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27037 (24-End)
      • expression tag (13-23)
    Domains in SCOPe 2.08: d3q4ta1, d3q4ta2
  • Chain 'B':
    Compound: Activin receptor type-2A
    Species: Homo sapiens [TaxId:9606]
    Gene: ACVR2, ACVR2A
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27037 (24-End)
      • expression tag (9-23)
    Domains in SCOPe 2.08: d3q4tb1, d3q4tb2
  • Heterogens: TAK, SO4, EDO, PG4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3q4tA (A:)
mghhhhhhssgvdlgtenlyfqsmplqllevkargrfgcvwkaqllneyvavkifpiqdk
qswqneyevyslpgmkhenilqfigaekrgtsvdvdlwlitafhekgslsdflkanvvsw
nelchiaetmarglaylhedipglkdghkpaishrdiksknvllknnltaciadfglalk
feagksagdthgqvgtrrymapevlegainfqrdaflridmyamglvlwelasrctaadg
pvdeymlpfeeeigqhpsledmqevvvhkkkrpvlrdywqkhagmamlcetieecwdhda
earlsagcvgeritqmqrltni

    Sequence, based on observed residues (ATOM records): (download) 
    >3q4tA (A:)
lgtenlyfqsmplqllevkargrfgcvwkaqllneyvavkifpiqdkqswqneyevyslp
gmkhenilqfigaekrgtsvdvdlwlitafhekgslsdflkanvvswnelchiaetmarg
laylhedipglkdghkpaishrdiksknvllknnltaciadfglalkfeagksagdthgq
vgtrrymapevlegainfqrdaflridmyamglvlwelasrctaadgpvdeymlpfeeei
gqhpsledmqevvvhkkkrpvlrdywqkhagmamlcetieecwdhdaearlsagcvgeri
tqmqr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3q4tB (B:)
mghhhhhhssgvdlgtenlyfqsmplqllevkargrfgcvwkaqllneyvavkifpiqdk
qswqneyevyslpgmkhenilqfigaekrgtsvdvdlwlitafhekgslsdflkanvvsw
nelchiaetmarglaylhedipglkdghkpaishrdiksknvllknnltaciadfglalk
feagksagdthgqvgtrrymapevlegainfqrdaflridmyamglvlwelasrctaadg
pvdeymlpfeeeigqhpsledmqevvvhkkkrpvlrdywqkhagmamlcetieecwdhda
earlsagcvgeritqmqrltni

    Sequence, based on observed residues (ATOM records): (download) 
    >3q4tB (B:)
sgvdlgtenlyfqsmplqllevkargrfgcvwkaqllneyvavkifpiqdkqswqneyev
yslpgmkhenilqfigaekrgtsvdvdlwlitafhekgslsdflkanvvswnelchiaet
marglaylhedipglkdghkpaishrdiksknvllknnltaciadfglalkfeagksath
gqvgtrrymapevlegainfqrdaflridmyamglvlwelasrctaadgpvdeymlpfee
eigqhpsledmqevvvhkkkrpvlrdywqkhagmamlcetieecwdhdaearlsagcvge
ritqmqrl