PDB entry 3q3b

View 3q3b on RCSB PDB site
Description: 6-Amino-4-(pyrimidin-4-yl)pyridones: Novel Glycogen Synthase Kinase-3 Inhibitors
Class: transferase/transferase inhibitor
Keywords: Kinase, Inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2010-12-21, released 2011-06-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-01-24, with a file datestamp of 2018-01-19.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glycogen synthase kinase-3 beta
    Species: Homo sapiens [TaxId:9606]
    Gene: GSK3B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3q3ba_
  • Chain 'B':
    Compound: Glycogen synthase kinase-3 beta
    Species: Homo sapiens [TaxId:9606]
    Gene: GSK3B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3q3bb_
  • Heterogens: 55E, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3q3bA (A:)
gplgssgrprttsfaesckpvqqpsafgsmkvsrdkdgskvttvvatpgqgpdrpqevsy
tdtkvigngsfgvvyqaklcdsgelvaikkvlqdkrfknrelqimrkldhcnivrlryff
yssgekkdevylnlvldyvpetvyrvarhysrakqtlpviyvklymyqlfrslayihsfg
ichrdikpqnllldpdtavlklcdfgsakqlvrgepnvsyicsryyrapelifgatdyts
sidvwsagcvlaelllgqpifpgdsgvdqlveiikvlgtptreqiremnpnytefkfpqi
kahpwtkvfrprtppeaialcsrlleytptarltpleacahsffdelrdpnvklpngrdt
palfnfttqelssnpplatilipphariqaaastptnataasdantgdrgqtnnaasasa
snst

    Sequence, based on observed residues (ATOM records): (download) 
    >3q3bA (A:)
skvttvvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikkvlqdkrfk
nrelqimrkldhcnivrlryffyssgevylnlvldyvpetvyrvarhysrakqtlpviyv
klymyqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakqlvrgepnvsyic
sryyrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdqlveiikvlgtptr
eqiremnpnkfpqikahpwtkvfrprtppeaialcsrlleytptarltpleacahsffde
lrdpnvklpngrdtpalfnfttqelssnpplatilipphariqa

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3q3bB (B:)
gplgssgrprttsfaesckpvqqpsafgsmkvsrdkdgskvttvvatpgqgpdrpqevsy
tdtkvigngsfgvvyqaklcdsgelvaikkvlqdkrfknrelqimrkldhcnivrlryff
yssgekkdevylnlvldyvpetvyrvarhysrakqtlpviyvklymyqlfrslayihsfg
ichrdikpqnllldpdtavlklcdfgsakqlvrgepnvsyicsryyrapelifgatdyts
sidvwsagcvlaelllgqpifpgdsgvdqlveiikvlgtptreqiremnpnytefkfpqi
kahpwtkvfrprtppeaialcsrlleytptarltpleacahsffdelrdpnvklpngrdt
palfnfttqelssnpplatilipphariqaaastptnataasdantgdrgqtnnaasasa
snst

    Sequence, based on observed residues (ATOM records): (download) 
    >3q3bB (B:)
skvttvvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikkvlqdkrfk
nrelqimrkldhcnivrlryffyssgdevylnlvldyvpetvyrvarhysrakqtlpviy
vklymyqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakqlvrgepnvsyi
csryyrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdqlveiikvlgtpt
reqiremnpkfpqikahpwtkvfrprtppeaialcsrlleytptarltpleacahsffde
lrdpnvklpngrdtpalfnfttqelssnpplatilipphar