PDB entry 3q1e

View 3q1e on RCSB PDB site
Description: Crystal structure of Y116T/I16A double mutant of 5-hydroxyisourate hydrolase in complex with T4
Class: hydrolase
Keywords: HIUASE, TRANSTHYRETIN, TRP, THYROID HORMONES, MOLECULAR EVOLUTION, PURINE METABOLISM, Greek key beta-barrel, Hydrolase, Point Mutation, peroxisome
Deposited on 2010-12-17, released 2011-05-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-01-01, with a file datestamp of 2019-12-27.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 5-hydroxyisourate hydrolase
    Species: Danio rerio [TaxId:7955]
    Gene: urah
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q06S87 (Start-118)
      • engineered mutation (15)
      • engineered mutation (115)
    Domains in SCOPe 2.08: d3q1ea_
  • Chain 'B':
    Compound: 5-hydroxyisourate hydrolase
    Species: Danio rerio [TaxId:7955]
    Gene: urah
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q06S87 (Start-118)
      • engineered mutation (15)
      • engineered mutation (115)
    Domains in SCOPe 2.08: d3q1eb_
  • Chain 'C':
    Compound: 5-hydroxyisourate hydrolase
    Species: Danio rerio [TaxId:7955]
    Gene: urah
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q06S87 (Start-118)
      • engineered mutation (15)
      • engineered mutation (115)
    Domains in SCOPe 2.08: d3q1ec_
  • Chain 'D':
    Compound: 5-hydroxyisourate hydrolase
    Species: Danio rerio [TaxId:7955]
    Gene: urah
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q06S87 (Start-118)
      • engineered mutation (15)
      • engineered mutation (115)
    Domains in SCOPe 2.08: d3q1ed_
  • Heterogens: T44, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3q1eA (A:)
    msatllsplsthvlnaaqgvpganmtivlhrldpvssawnilttgitnddgrcpglitke
    nfiagvykmrfetgkywdalgetcfypyveivftitntsqhyhvplllsrfsysttrgs
    

    Sequence, based on observed residues (ATOM records): (download)
    >3q1eA (A:)
    splsthvlnaaqgvpganmtivlhrldpvssawnilttgitnddgrcpglitkenfiagv
    ykmrfetgkywdalgetcfypyveivftitntsqhyhvplllsrfsysttrgs
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >3q1eB (B:)
    msatllsplsthvlnaaqgvpganmtivlhrldpvssawnilttgitnddgrcpglitke
    nfiagvykmrfetgkywdalgetcfypyveivftitntsqhyhvplllsrfsysttrgs
    

    Sequence, based on observed residues (ATOM records): (download)
    >3q1eB (B:)
    lsplsthvlnaaqgvpganmtivlhrldpvssawnilttgitnddgrcpglitkenfiag
    vykmrfetgkywdalgetcfypyveivftitntsqhyhvplllsrfsysttrgs
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >3q1eC (C:)
    msatllsplsthvlnaaqgvpganmtivlhrldpvssawnilttgitnddgrcpglitke
    nfiagvykmrfetgkywdalgetcfypyveivftitntsqhyhvplllsrfsysttrgs
    

    Sequence, based on observed residues (ATOM records): (download)
    >3q1eC (C:)
    lsplsthvlnaaqgvpganmtivlhrldpvssawnilttgitnddgrcpglitkenfiag
    vykmrfetgkywdalgetcfypyveivftitntsqhyhvplllsrfsysttrgs
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >3q1eD (D:)
    msatllsplsthvlnaaqgvpganmtivlhrldpvssawnilttgitnddgrcpglitke
    nfiagvykmrfetgkywdalgetcfypyveivftitntsqhyhvplllsrfsysttrgs
    

    Sequence, based on observed residues (ATOM records): (download)
    >3q1eD (D:)
    tllsplsthvlnaaqgvpganmtivlhrldpvssawnilttgitnddgrcpglitkenfi
    agvykmrfetgkywdalgetcfypyveivftitntsqhyhvplllsrfsysttrgs