PDB entry 3pwm

View 3pwm on RCSB PDB site
Description: HIV-1 Protease Mutant L76V with Darunavir
Class: hydrolase/hydrolase inhibitor
Keywords: HIV-1, protease, mutation L76V, darunavir, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2010-12-08, released 2011-04-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-06-08, with a file datestamp of 2011-06-03.
Experiment type: XRAY
Resolution: 1.46 Å
R-factor: 0.143
AEROSPACI score: 0.7 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Protease
  Species: Human immunodeficiency virus 1 [TaxId:11676]
  Gene: pol
  Database cross-references and differences (RAF-indexed):
  • Uniprot P03367
    • engineered mutation (6)
    • engineered mutation (32)
    • engineered mutation (62)
    • engineered mutation (66)
    • engineered mutation (75)
    • engineered mutation (94)
  Domains in SCOPe 2.08: d3pwma_
• Chain 'B':
  Compound: Protease
  Species: Human immunodeficiency virus 1 [TaxId:11676]
  Gene: pol
  Database cross-references and differences (RAF-indexed):
  • Uniprot P03367 (0-98)
    • engineered mutation (6)
    • engineered mutation (32)
    • engineered mutation (62)
    • engineered mutation (66)
    • engineered mutation (75)
    • engineered mutation (94)
  Domains in SCOPe 2.08: d3pwmb_
• Heterogens: CL, ACT, NA, 017, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >3pwmA (A:)
  pqitlwkrplvtikiggqlkealldtgaddtvieemslpgrwkpkmiggiggfikvrqyd
  qiiieiaghkaigtvvvgptpvniigrnlltqigatlnf
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >3pwmB (B:)
  pqitlwkrplvtikiggqlkealldtgaddtvieemslpgrwkpkmiggiggfikvrqyd
  qiiieiaghkaigtvvvgptpvniigrnlltqigatlnf