PDB entry 3pph

View 3pph on RCSB PDB site
Description: Crystal structure of the Candida albicans methionine synthase by surface entropy reduction, threonine variant
Class: transferase
Keywords: cobalamin-independent, Surface entropy reduction, Zn binding, TRANSFERASE
Deposited on 2010-11-24, released 2011-10-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-10-12, with a file datestamp of 2011-10-07.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.213
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
    Species: Candida albicans [TaxId:5476]
    Gene: CaO19.10083, CaO19.2551, MET6
    Database cross-references and differences (RAF-indexed):
    • Uniprot P82610 (22-End)
      • engineered mutation (124-125)
      • engineered mutation (128)
    Domains in SCOPe 2.08: d3ppha1, d3ppha2
  • Chain 'B':
    Compound: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
    Species: Candida albicans [TaxId:5476]
    Gene: CaO19.10083, CaO19.2551, MET6
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3pphb1, d3pphb2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3pphA (A:)
mhhhhhhssgvdlgtenlyfqsmvqssvlgfpriggqrelkkiteaywsgkatveellak
gkelrehnwklqqkagvdiipsndfsyydqvldlsllfnaiperytkfdlapidvlfamg
rglqttatttqaavdvtalemvkwfdsnyhyvrptfshstefklntaagikpvdefneak
algvqtrpvilgpvsylylgkadkdsldlepisllpkilpvykellqklkeagaeqvqid
epvlvldlpeavqskfkeaydalvgadvpelilttyfgdvrpnlkaienlpvagfhfdfv
rvpeqldevasilkdgqtlsagvvdgrniwktdfakasavvqkaiekvgkdkvvvatsss
llhtpvdlesetkldavikdwfsfatqkldevvviaknvsgedvskqleanaasikarse
ssitndpkvqerlttinealatrkaafperlteqkakynlplfptttigsfpqtkdirin
rnkfakgqitaeeyeafinkeietvvrfqeeigldvlvhgeperndmvqyfgeqlngfaf
ttngwvqsygsryvrppiivgdvsrpkamtvkesvyaqsitskpmkgmltgpvtilrwsf
prddvsgkiqalqlglalrdevndlegagitviqvdepaireglplragkersdylnwaa
qsfrvatsgvenstqihshfcysdldpnhikaldadvvsiefskkddpnyiqefseypnh
iglglfdihspripskqefvsrieeilkvypaskfwvnpdcglktrgwpevkesltnmve
aakefraky

    Sequence, based on observed residues (ATOM records): (download) 
    >3pphA (A:)
mvqssvlgfpriggqrelkkiteaywsgkatveellakgkelrehnwklqqkagvdiips
ndfsyydqvldlsllfnaiperytkfdlapidvlfamgrglqttatttqaavdvtalemv
kwfdsnyhyvrptfshstefklntaagikpvdefneakalgvqtrpvilgpvsylylgka
dkdsldlepisllpkilpvykellqklkeagaeqvqidepvlvldlpeavqskfkeayda
lvgadvpelilttyfgdvrpnlkaienlpvagfhfdfvrvpeqldevasilkdgqtlsag
vvdgrniwktdfakasavvqkaiekvgkdkvvvatsssllhtpvdlesetkldavikdwf
sfatqkldevvviaknvsgedvskqleanaasikarsessitndpkvqerlttinealat
rkaafperlteqkakynlplfptttigsfpqtkdirinrnkfakgqitaeeyeafinkei
etvvrfqeeigldvlvhgeperndmvqyfgeqlngfafttngwvqsygsryvrppiivgd
vsrpkamtvkesvyaqsitskpmkgmltgpvtilrwsfprddvsgkiqalqlglalrdev
ndlegagitviqvdepaireglplragkersdylnwaaqsfrvatsgvenstqihshfcy
ldpnhikaldadvvsiefskkddpnyiqefseypnhiglglfskqefvsrieeilkvypa
skfwvnpdcglktrgwpevkesltnmveaakefrak

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3pphB (B:)
mhhhhhhssgvdlgtenlyfqsmvqssvlgfpriggqrelkkiteaywsgkatveellak
gkelrehnwklqqkagvdiipsndfsyydqvldlsllfnaiperytkfdlapidvlfamg
rglqttatttqaavdvtalemvkwfdsnyhyvrptfshstefklntaagikpvdefneak
algvqtrpvilgpvsylylgkadkdsldlepisllpkilpvykellqklkeagaeqvqid
epvlvldlpeavqskfkeaydalvgadvpelilttyfgdvrpnlkaienlpvagfhfdfv
rvpeqldevasilkdgqtlsagvvdgrniwktdfakasavvqkaiekvgkdkvvvatsss
llhtpvdlesetkldavikdwfsfatqkldevvviaknvsgedvskqleanaasikarse
ssitndpkvqerlttinealatrkaafperlteqkakynlplfptttigsfpqtkdirin
rnkfakgqitaeeyeafinkeietvvrfqeeigldvlvhgeperndmvqyfgeqlngfaf
ttngwvqsygsryvrppiivgdvsrpkamtvkesvyaqsitskpmkgmltgpvtilrwsf
prddvsgkiqalqlglalrdevndlegagitviqvdepaireglplragkersdylnwaa
qsfrvatsgvenstqihshfcysdldpnhikaldadvvsiefskkddpnyiqefseypnh
iglglfdihspripskqefvsrieeilkvypaskfwvnpdcglktrgwpevkesltnmve
aakefraky

    Sequence, based on observed residues (ATOM records): (download) 
    >3pphB (B:)
mvqssvlgfpriggqrelkkiteaywsgkatveellakgkelrehnwklqqkagvdiips
ndfsyydqvldlsllfnaiperytkfdlapidvlfamgrglqvtalemvkwfdsnyhyvr
ptfshstefklntaagikpvdefneakalgvqtrpvilgpvsylylgkadkdsldlepis
llpkilpvykellqklkeagaeqvqidepvlvldlpeavqskfkeaydalvgadvpelil
ttyfgdvrpnlkaienlpvagfhfdfvrvpeqldevasilkdgqtlsagvvdgrniwktd
fakasavvqkaiekvgkdkvvvatsssllhtpvdlesetkldavikdwfsfatqkldevv
viaknvsgedvskqleanaasikarsessitndpkvqerlttinealatrkaafperlte
qkakynlplfptttigsfpqtkdirinrnkfakgqitaeeyeafinkeietvvrfqeeig
ldvlvhgeperndmvqyfgeqlngfafttngwvqsygsryvrppiivgdvsrpkamtvke
svyaqsitskpmkgmltgpvtilrwsfprddvsgkiqalqlglalrdevndlegagitvi
qvdepaireglplragkersdylnwaaqsfrvatsgvenstqihshfcyldpnhikalda
dvvsiefskkddpnyiqefseypnhiglglfpskqefvsrieeilkvypaskfwvnpdcg
lktrgwpevkesltnmveaakefraky