PDB entry 3pj3
View 3pj3 on RCSB PDB site
Description: Crystal structure of BTK kinase domain complexed with 2-Methyl-5-[(E)-(3-phenyl-acryloyl)amino]-N-(2-phenyl-3H-imidazo[4,5-b]pyridin-6-yl)-benzamide
Class: transferase/inhibitor
Keywords: helix C-in, DFG-out, TRANSFERASE, TRANSFERASE-INHIBITOR complex
Deposited on
2010-11-08, released
2011-01-12
The last revision prior to the SCOPe 2.02 freeze date was dated
2011-04-27, with a file datestamp of
2011-04-22.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: 0.234
AEROSPACI score: 0.46
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Tyrosine-protein kinase BTK
Species: Homo sapiens [TaxId:9606]
Gene: AGMX1, ATK, BPK, BTK
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.02: d3pj3a_ - Heterogens: 04L, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3pj3A (A:)
gtaglgygsweidpkdltflkelgtgqfgvvkygkwrgqydvaikmikegsmsedefiee
akvmmnlsheklvqlygvctkqrpifiiteymangcllnylremrhrfqtqqllemckdv
ceameyleskqflhrdlaarnclvndqgvvkvsdfglsryvlddeytssvgskfpvrwsp
pevlmyskfssksdiwafgvlmweiyslgkmpyerftnsetaehiaqglrlyrphlasek
vytimyscwhekaderptfkillsnildvmdees
Sequence, based on observed residues (ATOM records): (download)
>3pj3A (A:)
gygsweidpkdltflkelgtgvvkygkwrgqydvaikmidefieeakvmmnlsheklvql
ygvctkqrpifiiteymangcllnylremrhrfqtqqllemckdvceameyleskqflhr
dlaarnclvndqgvvkvsdfpvrwsppevlmyskfssksdiwafgvlmweiyslgkmpye
rftnsetaehiaqglrlyrphlasekvytimyscwhekaderptfkillsnildvmdees