PDB entry 3pj2
View 3pj2 on RCSB PDB site
Description: Crystal structure of BTK kinase domain complexed with 2-[4-(2-Diethylamino-ethoxy)-phenylamino]-6-(4-fluoro-phenoxy)-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one
Class: transferase/inhibitor
Keywords: helix C-out, DFG-in, TRANSFERASE, TRANSFERASE-INHIBITOR complex
Deposited on
2010-11-08, released
2011-01-12
The last revision prior to the SCOPe 2.05 freeze date was dated
2011-04-27, with a file datestamp of
2011-04-22.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: 0.231
AEROSPACI score: 0.49
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Tyrosine-protein kinase BTK
Species: Homo sapiens [TaxId:9606]
Gene: AGMX1, ATK, BPK, BTK
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d3pj2a_ - Heterogens: 04K, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3pj2A (A:)
gtaglgygsweidpkdltflkelgtgqfgvvkygkwrgqydvaikmikegsmsedefiee
akvmmnlsheklvqlygvctkqrpifiiteymangcllnylremrhrfqtqqllemckdv
ceameyleskqflhrdlaarnclvndqgvvkvsdfglsryvlddeytssvgskfpvrwsp
pevlmyskfssksdiwafgvlmweiyslgkmpyerftnsetaehiaqglrlyrphlasek
vytimyscwhekaderptfkillsnildvmdees
Sequence, based on observed residues (ATOM records): (download)
>3pj2A (A:)
gygsweidpkdltflkelgtgvvkygkwrgqydvaikmikegsmsedefieeakvmmnls
heklvqlygvctkqrpifiiteymangcllnylremrhrfqtqqllemckdvceameyle
skqflhrdlaarnclvndqgvvkvsdffpvrwsppevlmyskfssksdiwafgvlmweiy
slgkmpyerftnsetaehiaqglrlyrphlasekvytimyscwhekaderptfkillsni
ldvmdees