PDB entry 3piz

View 3piz on RCSB PDB site
Description: Crystal structure of BTK kinase domain complexed with (5-Amino-1-o-tolyl-1H-pyrazol-4-yl)-[3-(1-methanesulfonyl-piperidin-4-yl)-phenyl]-methanone
Class: transferase/inhibitor
Keywords: helix C-in, DFG-in, TRANSFERASE, TRANSFERASE-INHIBITOR complex
Deposited on 2010-11-08, released 2011-01-12
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-04-27, with a file datestamp of 2011-04-22.
Experiment type: XRAY
Resolution: 2.21 Å
R-factor: 0.228
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase BTK
    Species: Homo sapiens [TaxId:9606]
    Gene: AGMX1, ATK, BPK, BTK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3piza_
  • Heterogens: 03C, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3pizA (A:)
    gtaglgygsweidpkdltflkelgtgqfgvvkygkwrgqydvaikmikegsmsedefiee
    akvmmnlsheklvqlygvctkqrpifiiteymangcllnylremrhrfqtqqllemckdv
    ceameyleskqflhrdlaarnclvndqgvvkvsdfglsryvlddeytssvgskfpvrwsp
    pevlmyskfssksdiwafgvlmweiyslgkmpyerftnsetaehiaqglrlyrphlasek
    vytimyscwhekaderptfkillsnildvmdees
    

    Sequence, based on observed residues (ATOM records): (download)
    >3pizA (A:)
    gygsweidpkdltflkelgtgvvkygkwrgqydvaikmisedefieeakvmmnlsheklv
    qlygvctkqrpifiiteymangcllnylremrhrfqtqqllemckdvceameyleskqfl
    hrdlaarnclvndqgvvkvsdfglfpvrwsppevlmyskfssksdiwafgvlmweiyslg
    kmpyerftnsetaehiaqglrlyrphlasekvytimyscwhekaderptfkillsnildv
    mdees