PDB entry 3pfp

View 3pfp on RCSB PDB site
Description: Structure of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis in complex with an active site inhibitor
Class: transferase/transferase inhibitor
Keywords: Shikimate pathway, Mycobacterium tuberculosis, DAH7P synthase, Aromatic biosynthesis, TIM barrel, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2010-10-28, released 2011-03-16
The last revision prior to the SCOPe 2.04 freeze date was dated 2012-02-22, with a file datestamp of 2012-02-17.
Experiment type: XRAY
Resolution: 2.35 Å
R-factor: 0.164
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Probable 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroG
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: aroG, Rv2178c
    Database cross-references and differences (RAF-indexed):
    • Uniprot O53512 (2-463)
      • expression tag (0-1)
    Domains in SCOPe 2.04: d3pfpa_
  • Chain 'B':
    Compound: Probable 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroG
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: aroG, Rv2178c
    Database cross-references and differences (RAF-indexed):
    • Uniprot O53512 (2-463)
      • expression tag (0-1)
    Domains in SCOPe 2.04: d3pfpb_
  • Heterogens: MN, 035, 036, CL, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3pfpA (A:)
gamnwtvdipidqlpslpplptdlrtrldaalakpaaqqptwpadqalamrtvlesvppv
tvpseivrlqeqlaqvakgeafllqggdcaetfmdntephirgnvrallqmavvltygas
mpvvkvariagqyakprsadidalglrsyrgdmingfapdaaarehdpsrlvrayanasa
amnlvraltssglaslhlvhdwnrefvrtspagaryealateidrglrfmsacgvadrnl
qtaeiyashealvldyeramlrlsdgddgepqlfdlsahtvwigertrqidgahiafaqv
ianpvgvklgpnmtpelaveyverldphnkpgrltlvsrmgnhkvrdllppivekvqatg
hqviwqcdpmhgnthesstgfktrhfdrivdevqgffevhralgthpggihveitgenvt
eclggaqdisetdlagryetacdprlntqqslelaflvaemlrd

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3pfpB (B:)
gamnwtvdipidqlpslpplptdlrtrldaalakpaaqqptwpadqalamrtvlesvppv
tvpseivrlqeqlaqvakgeafllqggdcaetfmdntephirgnvrallqmavvltygas
mpvvkvariagqyakprsadidalglrsyrgdmingfapdaaarehdpsrlvrayanasa
amnlvraltssglaslhlvhdwnrefvrtspagaryealateidrglrfmsacgvadrnl
qtaeiyashealvldyeramlrlsdgddgepqlfdlsahtvwigertrqidgahiafaqv
ianpvgvklgpnmtpelaveyverldphnkpgrltlvsrmgnhkvrdllppivekvqatg
hqviwqcdpmhgnthesstgfktrhfdrivdevqgffevhralgthpggihveitgenvt
eclggaqdisetdlagryetacdprlntqqslelaflvaemlrd