PDB entry 3pdj
View 3pdj on RCSB PDB site
Description: Crystal Structure of Human 11-beta-Hydroxysteroid Dehydrogenase 1 (11b-HSD1) in Complex with 4,4-Disubstituted Cyclohexylbenzamide Inhibitor
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: 11beta, hydroxysteroid, dehydrogenase, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Deposited on
2010-10-22, released
2011-10-05
The last revision prior to the SCOPe 2.08 freeze date was dated
2011-10-05, with a file datestamp of
2011-09-30.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.212
AEROSPACI score: 0.35
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Corticosteroid 11-beta-dehydrogenase isozyme 1
Species: Homo sapiens [TaxId:9606]
Gene: HSD11, HSD11B1, HSD11L
Database cross-references and differences (RAF-indexed):
- Uniprot P28845 (4-End)
- expression tag (0-3)
- engineered mutation (252)
Domains in SCOPe 2.08: d3pdja1, d3pdja2 - Chain 'B':
Compound: Corticosteroid 11-beta-dehydrogenase isozyme 1
Species: Homo sapiens [TaxId:9606]
Gene: HSD11, HSD11B1, HSD11L
Database cross-references and differences (RAF-indexed):
- Uniprot P28845 (4-272)
- expression tag (1-3)
- engineered mutation (252)
Domains in SCOPe 2.08: d3pdjb1, d3pdjb2 - Heterogens: 3PJ, NAP, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3pdjA (A:)
qqplneefrpemlqgkkvivtgaskgigremayhlakmgahvvvtarsketlqkvvshcl
elgaasahyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddihhvrks
mevnflsyvvltvaalpmlkqsngsivvvsslagkvaypmvaaysaskfaldgffssirk
eysvsrvnvsitlcvlglidtetamkavsgivhmqaapkeecaleiikggalrqeevyyd
sslwttllirnpsrkileflystsynmdrfink
Sequence, based on observed residues (ATOM records): (download)
>3pdjA (A:)
qqplneefrpemlqgkkvivtgaskgigremayhlakmgahvvvtarsketlqkvvshcl
elgaasahyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddihhvrks
mevnflsyvvltvaalpmlkqsngsivvvsslagkvaypmvaaysaskfaldgffssirk
eysvsrvnvsitlcvlglidtetamkavsgivhmqaapkeecaleiikggalrqeevyyd
sslwttllirnpsrkileflystsynmdrfin
- Chain 'B':
Sequence, based on SEQRES records: (download)
>3pdjB (B:)
qqplneefrpemlqgkkvivtgaskgigremayhlakmgahvvvtarsketlqkvvshcl
elgaasahyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddihhvrks
mevnflsyvvltvaalpmlkqsngsivvvsslagkvaypmvaaysaskfaldgffssirk
eysvsrvnvsitlcvlglidtetamkavsgivhmqaapkeecaleiikggalrqeevyyd
sslwttllirnpsrkileflystsynmdrfink
Sequence, based on observed residues (ATOM records): (download)
>3pdjB (B:)
qplneefrpemlqgkkvivtgaskgigremayhlakmgahvvvtarsketlqkvvshcle
lgaasahyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddihhvrksm
evnflsyvvltvaalpmlkqsngsivvvsslagkvaypmvaaysaskfaldgffssirke
ysvsrvnvsitlcvlglidtetamkavsgivhmqaapkeecaleiikggalrqeevyyds
slwttllirnpsrkileflystsynmdrfink