PDB entry 3p8x

View 3p8x on RCSB PDB site
Description: Synthesis, Structure, and Biological Activity of des-Side Chain Analogues of 1alpha,25-Dihydroxyvitamin D3 with Substituents at C-18
Class: Transcription Regulator
Keywords: helices sandwich, transcription regulation, vitamin D, Transcription Regulator
Deposited on 2010-10-15, released 2011-08-31
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-08-31, with a file datestamp of 2011-08-26.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: 0.189
AEROSPACI score: 0.57 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Vitamin D3 receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: Vdr, Nr1i1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11473 (21-67)
    • Uniprot P11473 (69-End)
      • expression tag (68)
    Domains in SCOPe 2.06: d3p8xa_
  • Heterogens: ZYD, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3p8xA (A:)
mgsshhhhhhssglvprgshmdslrpklseeqqriiailldahhktydptysdfcqfrpp
vrvndgggsvtlelsqlsmlphladlvsysiqkvigfakmipgfrdltsedqivllkssa
ievimlrsnesftmddmswtcgnqdykyrvsdvtkaghslelieplikfqvglkklnlhe
eehvllmaicivspdrpgvqdaalieaiqdrlsntlqtyircrhpppgshllyakmiqkl
adlrslneehskqyrclsfqpecsmkltplvlevfgneis

    Sequence, based on observed residues (ATOM records): (download) 
    >3p8xA (A:)
dslrpklseeqqriiailldahhktydptysdfcqfrppvrvndgggsvtlelsqlsmlp
hladlvsysiqkvigfakmipgfrdltsedqivllkssaievimlrsnesftmddmswtc
gnqdykyrvsdvtkaghslelieplikfqvglkklnlheeehvllmaicivspdrpgvqd
aalieaiqdrlsntlqtyircrhpppgshllyakmiqkladlrslneehskqyrclsfqp
ecsmkltplvlevfg