PDB entry 3p71

View 3p71 on RCSB PDB site
Description: Crystal structure of the complex of LCMT-1 and PP2A
Class: transferase/hydrolase
Keywords: LEUCINE CARBOXYMETHYLTRANSFERASE-1,SERINE/THREONINE PROTEIN KEYWDS 2 PHOSPHATASE 2A, METHYLTRANSFERASE, S-ADENOSYL-L-METHIONINE, TRANSFERASE-HYDROLASE complex
Deposited on 2010-10-11, released 2011-02-16
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-10-15, with a file datestamp of 2014-10-10.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.195
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'C':
    Compound: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP2CA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3p71c_
  • Chain 'T':
    Compound: Leucine carboxyl methyltransferase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: CGI-68, LCMT, LCMT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UIC8 (Start-333)
      • engineered mutation (20-21)
      • engineered mutation (114)
    Domains in SCOPe 2.08: d3p71t_
  • Heterogens: PEG, AN6, MN, HOH

PDB Chain Sequences:

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3p71C (C:)
mdekvftkeldqwieqlneckqlsesqvkslcekakeiltkesnvqevrcpvtvcgdvhg
qfhdlmelfriggkspdtnylfmgdyvdrgyysvetvtllvalkvryreritilrgnhes
rqitqvygfydeclrkygnanvwkyftdlfdylpltalvdgqifclhgglspsidtldhi
raldrlqevphegpmcdllwsdpddrggwgisprgagytfgqdisetfnhangltlvsra
hqlvmegynwchdrnvvtifsapnycyrcgnqaaimelddtlkysflqfdpaphvtrrtp
dyfl

    Sequence, based on observed residues (ATOM records): (download) 
    >3p71C (C:)
dekvftkeldqwieqlneckqlsesqvkslcekakeiltkesnvqevrcpvtvcgdvhgq
fhdlmelfriggkspdtnylfmgdyvdrgyysvetvtllvalkvryreritilrgnhesr
qitqvygfydeclrkygnanvwkyftdlfdylpltalvdgqifclhgglspsidtldhir
aldrlqevphegpmcdllwsdpddrggwgisprgagytfgqdisetfnhangltlvsrah
qlvmegynwchdrnvvtifsapnycyrcgnqaaimelddtlkysflqfdpaphvtrrtpd
yfl

  • Chain 'T':
    Sequence, based on SEQRES records: (download) 
    >3p71T (T:)
matrqressitsccstssmdendegvrgtcedaslckrfavsigywhdpyiqhfvrlske
rkapeinrgyfarvhgvsqlikaflrktechcqivnlgagmdttfwrlkdedllsskyfe
vdfpmivtrklhsikckpplsspilelhsedtlqmdghildskryavigadlrdlselee
klkkcnmntqlptlliaecvlvymtpeqsanllkwaansferamfinyeqvnmgdrfgqi
mienlrrrqcdlagvetckslesqkerllsngwetasavdmmelynrlpraevsriesle
fldemelleqlmrhyclcwatkggnelglkeity

    Sequence, based on observed residues (ATOM records): (download) 
    >3p71T (T:)
dendegvrgtcedaslckrfavsigywhdpyiqhfvrlskerkapeinrgyfarvhgvsq
likaflrktechcqivnlgagmdttfwrlkdedllsskyfevdfpmivtrklhsikckpp
lsspilelhsedtlqmdghildskryavigadlrdlseleeklkkcnmntqlptlliaec
vlvymtpeqsanllkwaansferamfinyeqvnmgdrfgqimienlrrrqcdlagvetck
slesqkerllsngwetasavdmmelynrlpraevsrieslefldemelleqlmrhyclcw
atkggnelglkeity