PDB entry 3ozr

View 3ozr on RCSB PDB site
Description: Rat catechol O-methyltransferase in complex with a catechol-type, bisubstrate inhibitor, no substituent in the adenine site - humanized form
Class: transferase/transferase inhibitor
Keywords: METHYLTRANSFERASE, NEUROTRANSMITTER DEGRADATION, ALTERNATIVE INITIATION, CATECHOLAMINE METABOLISM, CELL MEMBRANE, MAGNESIUM, METAL-BINDING, S-ADENOSYL-L-METHIONINE, SIGNAL-ANCHOR, TRANSFERASE, TRANSMEMBRANE METHYLTRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2010-09-27, released 2011-03-16
The last revision prior to the SCOPe 2.04 freeze date was dated 2012-08-15, with a file datestamp of 2012-08-10.
Experiment type: XRAY
Resolution: 1.73 Å
R-factor: 0.196
AEROSPACI score: 0.53 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Catechol O-methyltransferase
  Species: Rattus norvegicus [TaxId:10116]
  Gene: COMT
  Database cross-references and differences (RAF-indexed):
  • Uniprot P22734
    • engineered mutation (90)
    • engineered mutation (94)
  Domains in SCOPe 2.04: d3ozra_
• Heterogens: MG, CL, OZR, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence, based on SEQRES records: (download)
  

  >3ozrA (A:)
  mgdtkeqrilryvqqnakpgdpqsvleaidtyctqkewamnvgdakgqimdavireysps
  lvlelgaycgysavrmarllqpgarlltmeinpdcaaitqqmlnfaglqdkvtilngasq
  dlipqlkkkydvdtldmvfldhwkdrylpdtlllekcgllrkgtvlladnvivpgtpdfl
  ayvrgsssfecthyssyleymkvvdglekaiyqgpsspdks
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >3ozrA (A:)
  dtkeqrilryvqqnakpgdpqsvleaidtyctqkewamnvgdakgqimdavireyspslv
  lelgaycgysavrmarllqpgarlltmeinpdcaaitqqmlnfaglqdkvtilngasqdl
  ipqlkkkydvdtldmvfldhwkdrylpdtlllekcgllrkgtvlladnvivpgtpdflay
  vrgsssfecthyssyleymkvvdglekaiyqgp