PDB entry 3oxz

View 3oxz on RCSB PDB site
Description: Crystal structure of ABL kinase domain bound with a DFG-out inhibitor AP24534
Class: transferase/transferase inhibitor
Keywords: protein-inhibitor complex, protein kinase two-domain fold, phosphotransferase, ATP binding, phosphorylation, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2010-09-22, released 2010-12-15
The last revision prior to the SCOPe 2.04 freeze date was dated 2010-12-22, with a file datestamp of 2010-12-17.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.218
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase ABL1
    Species: Mus musculus [TaxId:10090]
    Gene: Abl1, Abl
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00520 (1-283)
      • expression tag (0)
    Domains in SCOPe 2.04: d3oxza_
  • Heterogens: 0LI, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3oxzA (A:)
    gspnydkwemertditmkhklgggqygevyegvwkkysltvavktlkedtmeveeflkea
    avmkeikhpnlvqllgvctreppfyiitefmtygnlldylrecnrqevsavvllymatqi
    ssameylekknfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwta
    peslaynkfsiksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpek
    vyelmracwqwnpsdrpsfaeihqafetmfqessisdevekelg
    

    Sequence, based on observed residues (ATOM records): (download)
    >3oxzA (A:)
    gspnydkwemertditmkhklgggqygevyegvwkkysltvavktlveeflkeaavmkei
    khpnlvqllgvctreppfyiitefmtygnlldylrecnrqevsavvllymatqissamey
    lekknfihrdlaarnclvgenhlvkvadfglsytgakfpikwtapeslaynkfsiksdvw
    afgvllweiatygmspypgidlsqvyellekdyrmerpegcpekvyelmracwqwnpsdr
    psfaeihqafetmfqessisdevekelg