PDB entry 3ox2

View 3ox2 on RCSB PDB site
Description: X-ray Structural study of quinone reductase II inhibition by compounds with micromolar to nanomolar range IC50 values
Class: oxidoreductase
Keywords: qr2, nq02, flavoprotein, metal-2 binding, oxidoreductase, phosphoprotein, fad
Deposited on 2010-09-21, released 2011-05-25
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-06, with a file datestamp of 2011-07-01.
Experiment type: XRAY
Resolution: 2.41 Å
R-factor: 0.167
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Ribosyldihydronicotinamide dehydrogenase [quinone]
    Species: Homo sapiens [TaxId:9606]
    Gene: NQO2, NMOR2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3ox2a_
  • Chain 'B':
    Compound: Ribosyldihydronicotinamide dehydrogenase [quinone]
    Species: Homo sapiens [TaxId:9606]
    Gene: NQO2, NMOR2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3ox2b_
  • Heterogens: ZN, FAD, 79X, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3ox2A (A:)
magkkvlivyahqepksfngslknvavdelsrqgctvtvsdlyamnfepratdkditgtl
snpevfnygvetheaykqrslasditdeqkkvreadlvifqfplywfsvpailkgwmdrv
lcqgfafdipgfydsgllqgklallsvttggtaemytktgvngdsryflwplqhgtlhfc
gfkvlapqisfapeiaseeerkgmvaawsqrlqtiwkeepipctahwhfgq

    Sequence, based on observed residues (ATOM records): (download) 
    >3ox2A (A:)
agkkvlivyahqepksfngslknvavdelsrqgctvtvsdlyamnfepratdkditgtls
npevfnygvetheaykqrslasditdeqkkvreadlvifqfplywfsvpailkgwmdrvl
cqgfafdipgfydsgllqgklallsvttggtaemytktgvngdsryflwplqhgtlhfcg
fkvlapqisfapeiaseeerkgmvaawsqrlqtiwkeepipctahwhfgq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3ox2B (B:)
magkkvlivyahqepksfngslknvavdelsrqgctvtvsdlyamnfepratdkditgtl
snpevfnygvetheaykqrslasditdeqkkvreadlvifqfplywfsvpailkgwmdrv
lcqgfafdipgfydsgllqgklallsvttggtaemytktgvngdsryflwplqhgtlhfc
gfkvlapqisfapeiaseeerkgmvaawsqrlqtiwkeepipctahwhfgq

    Sequence, based on observed residues (ATOM records): (download) 
    >3ox2B (B:)
agkkvlivyahqepksfngslknvavdelsrqgctvtvsdlyamnfepratdkditgtls
npevfnygvetheaykqrslasditdeqkkvreadlvifqfplywfsvpailkgwmdrvl
cqgfafdipgfydsgllqgklallsvttggtaemytktgvngdsryflwplqhgtlhfcg
fkvlapqisfapeiaseeerkgmvaawsqrlqtiwkeepipctahwhfgq